From straight to curved: A historical perspective of DNA shape.

Autor: Benvenuti JL; Universidade de Caxias do Sul. Petrópolis, Caxias do Sul, Rio Grande do Sul, Brazil. Electronic address: jlbenvenuti@ucs.br., Casa PL; Universidade de Caxias do Sul. Petrópolis, Caxias do Sul, Rio Grande do Sul, Brazil., Pessi de Abreu F; Universidade de Caxias do Sul. Petrópolis, Caxias do Sul, Rio Grande do Sul, Brazil; Instituto de Biociências, Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Martinez GS; Universidade de Caxias do Sul. Petrópolis, Caxias do Sul, Rio Grande do Sul, Brazil., de Avila E Silva S; Universidade de Caxias do Sul. Petrópolis, Caxias do Sul, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Progress in biophysics and molecular biology [Prog Biophys Mol Biol] 2024 Nov; Vol. 193, pp. 46-54. Date of Electronic Publication: 2024 Sep 10.
DOI: 10.1016/j.pbiomolbio.2024.09.002
Abstrakt: DNA is the macromolecule responsible for storing the genetic information of a cell and it has intrinsic properties such as deformability, stability and curvature. DNA Curvature plays an important role in gene transcription and, consequently, in the subsequent production of proteins, a fundamental process of cells. With recent advances in bioinformatics and theoretical biology, it became possible to analyze and understand the involvement of DNA Curvature as a discriminatory characteristic of gene-promoting regions. These regions act as sites where RNAp (ribonucleic acid-polymerase) binds to initiate transcription. This review aims to describe the formation of Curvature, as well as highlight its importance in predicting promoters. Furthermore, this article provides the potential of DNA Curvature as a distinguishing feature for promoter prediction tools, as well as outlining the calculation procedures that have been described by other researchers. This work may support further studies directed towards the enhancement of promoter prediction software.
Competing Interests: Declaration of competing interest All authors declare that they have no conflicts of interest regarding the submission of this manuscript.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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