Updated review on pulmonary arterial hypertension: Differences between down syndrome and non-down syndrome populations.

Autor: Cueto-Robledo G; Hospital General de México, Cardiorespiratory Emergencies, 06720, Mexico City, Mexico; Hospital General de México, Pulmonary Circulation Clinic, 06720, Mexico City, Mexico; National Autonomous University of Mexico, Faculty of Medicine, 04510, Mexico City, Mexico. Electronic address: gmocue3@hotmail.com., Roldan-Valadez E; Instituto Nacional de Rehabilitación, Division of Research, 14389, Mexico City, Mexico; I.M. Sechenov First Moscow State Medical University (Sechenov University), Radiology Department, 119992, Moscow, Russia. Electronic address: ernest.roldan@usa.net., Garcia-Lezama M; Department of Surgery, Centro Médico Nacional La Raza, P.° de las Jacarandas S/N, La Raza, Azcapotzalco, 02990, Mexico City, Mexico. Electronic address: melissa.garcia.lezama@uabc.edu.mx., Garcia-Cesar M; Hospital General de México, Cardiorespiratory Emergencies, 06720, Mexico City, Mexico. Electronic address: Shak_mary@hotmail.com., Navarro-Vergara DI; Hospital General de México, Cardiorespiratory Emergencies, 06720, Mexico City, Mexico. Electronic address: dulceiliana@hotmail.com., Torres-Rojas MB; Hospital General de México, Cardiorespiratory Emergencies, 06720, Mexico City, Mexico. Electronic address: Beretorres.m.d@hotmail.com.
Jazyk: angličtina
Zdroj: Current problems in cardiology [Curr Probl Cardiol] 2024 Dec; Vol. 49 (12), pp. 102840. Date of Electronic Publication: 2024 Sep 10.
DOI: 10.1016/j.cpcardiol.2024.102840
Abstrakt: Background: Pulmonary arterial hypertension (PAH) is a major concern in patients with Down syndrome (DS) and congenital heart disease (CHD). Understanding the unique characteristics of PAH in these populations is essential for developing tailored management strategies. This review examines differences in PAH between DS and non-DS (nDS) patients with CHD, focusing on pathophysiology, clinical presentation, hemodynamic profiles, and treatment outcomes.
Methods: A retrospective analysis of 93 adults with PAH was conducted, including 18 with DS and 75 with CHD but without DS (nDS). Data on demographics, clinical presentations, comorbidities, and hemodynamic parameters were collected using echocardiography and right heart catheterization. Statistical analyses included Mann-Whitney U tests, Student's t-tests, and Kaplan-Meier survival analysis to compare the DS and nDS groups.
Results: DS patients presented with PAH at a younger age (mean age 25.06 years) compared to nDS patients (mean age 42.4 years; p < 0.001). Hypothyroidism was more prevalent in DS patients (61.1 %) than in nDS patients (29.3 %; p = 0.012). Hemodynamic assessments showed lower mean arterial pressure (MAP) in DS patients (76.24 ± 11.6 mmHg) versus nDS patients (93.95 ± 15 mmHg; p < 0.001), and a higher TAPSE/PASP ratio (0.41 vs. 0.23; p = 0.009), suggesting less severe right ventricular dysfunction. DS patients had a significant survival advantage over nDS patients (p = 0.043).
Conclusions: DS patients have distinct clinical and hemodynamic profiles in PAH, requiring personalized management. Early detection and tailored treatment are crucial for improving outcomes. Further research should refine these strategies and explore new therapies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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