CXCR4-Targeted PET Imaging in Hematologic Malignancies: A Systematic Review and Meta-analysis.

Autor:	Chavoshi M; From the Joint Department of Medical Imaging, University Medical Imaging Toronto, University Health Network, Mount Sinai Hospital & Women's College Hospital, University of Toronto, Toronto, Ontario, Canada., Mirshahvalad SA; From the Joint Department of Medical Imaging, University Medical Imaging Toronto, University Health Network, Mount Sinai Hospital & Women's College Hospital, University of Toronto, Toronto, Ontario, Canada., Kohan A; From the Joint Department of Medical Imaging, University Medical Imaging Toronto, University Health Network, Mount Sinai Hospital & Women's College Hospital, University of Toronto, Toronto, Ontario, Canada., Ortega C; From the Joint Department of Medical Imaging, University Medical Imaging Toronto, University Health Network, Mount Sinai Hospital & Women's College Hospital, University of Toronto, Toronto, Ontario, Canada., Metser U; From the Joint Department of Medical Imaging, University Medical Imaging Toronto, University Health Network, Mount Sinai Hospital & Women's College Hospital, University of Toronto, Toronto, Ontario, Canada., Farag A; From the Joint Department of Medical Imaging, University Medical Imaging Toronto, University Health Network, Mount Sinai Hospital & Women's College Hospital, University of Toronto, Toronto, Ontario, Canada., Kridel R; Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Hodgson D; Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Bhella S; Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Kukreti V; Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Veit-Haibach P; From the Joint Department of Medical Imaging, University Medical Imaging Toronto, University Health Network, Mount Sinai Hospital & Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Clinical nuclear medicine [Clin Nucl Med] 2025 Jan 01; Vol. 50 (1), pp. e7-e16. Date of Electronic Publication: 2024 Sep 11.
DOI:	10.1097/RLU.0000000000005426
Abstrakt:	Purpose: The aims of this study were to perform a comprehensive review and meta-analyses and to report pooled diagnostic results on CXCR4-targeted PET, particularly considering detection, visualization, and prognostication. Patients and Methods: This study followed PRISMA-DTA. A systematic search was conducted on major medical literature databases up to March 1, 2024. The search strategy was designed to include CXCR4 PET studies in hematologic malignancies. A random-effects model combined sensitivity values derived from 2-by-2 contingency tables. Pooled means for SUV max were computed. Analyses were performed by R software. Results: The initial search resulted in a total of 1428 studies. Ultimately, 18 were eligible for systematic review and meta-analytic calculations. Twelve studies (320 patients) included B-cell lymphoma. The pooled detection rate of CXCR4 PET was 99.4% (95% confidence interval [CI]: 88.3%-100%). Marginal zone lymphoma was investigated in 5 studies (209 patients), with a pooled sensitivity of 97.6% (95% CI: 79.7%-99.8%). In studies on central nervous system lymphoma, CXCR4 PET demonstrated 100% accuracy at both patient and lesion levels. Also, it demonstrated a significantly higher tumor-to-background ratio than 18 F-FDG PET. For multiple myeloma, 5 studies (116 patients) showed a patient-level pooled sensitivity of 77.8% (95% CI: 64.4%-87.2%), whereas 18 F-FDG PET had 65.0% (95% CI: 55.2%-73.7%). The pooled SUV max for CXCR4 PET was 13.6 (95% CI: 9.3-17.8) versus 9.0 (95% CI: 6.3-11.7) for 18 F-FDG PET. Additionally, CXCR4 PET-derived parameters were significant predictors of survival in multiple myeloma. Conclusions: CXCR4 PET can be a helpful imaging tool for evaluating hematologic malignancies, particularly in B-cell lymphoma and multiple myeloma patients. In specific clinical scenarios, it appears to be superior compared with the current standard-of-care imaging. Competing Interests: Conflicts of interest and sources of funding: The authors have no financial, personal, or professional affiliations that could be perceived as directly biasing this study or its findings. P.V.-H. received IIS trial support from Pentixapharm; speaker fees and travel support from Siemens Healthineers and GE Healthcare; speaker fees from Ontario Association of Radiologists. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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