Statistically Significant Associations Between HPV33, HPV35, and HPV56 With Anal HSIL in a Population of MSMLWH.

Autor:	Jair K; George Washington University, School of Public Health, Department of Epidemiology, Washington, DC., Abbott SE; Whitman-Walker Health, Washington, DC., Aldous A; George Washington University, School of Public Health, Department of Biostatistics and Bioinformatics, Washington, DC., Rivas KI; George Washington University, School of Public Health, Department of Epidemiology, Washington, DC., Connors KA; George Washington University, School of Public Health, Department of Epidemiology, Washington, DC., Klein DA; Whitman-Walker Health, Washington, DC., Hoke ES; Whitman-Walker Health, Washington, DC., Jordan JA; George Washington University, School of Public Health, Department of Epidemiology, Washington, DC.
Jazyk:	angličtina
Zdroj:	Journal of lower genital tract disease [J Low Genit Tract Dis] 2024 Sep 11. Date of Electronic Publication: 2024 Sep 11.
DOI:	10.1097/LGT.0000000000000837
Abstrakt:	Objective: The aim of the study is to determine the prevalence of high-risk human papillomavirus (hrHPV) genotypes in men who have sex with other men and are living with HIV and the factors associated with anal high-grade squamous intraepithelial lesions (HSIL). Methods: Anal swabs were collected for hrHPV genotyping from a cross-sectional group (N = 163) of eligible men who have sex with other men and are living with HIV attending a high-resolution anoscopy clinic. Persistent hrHPV infections were studied in a longitudinal subset (n = 37). Association of anal HSIL with specific hrHPV genotype(s) and with HIV-1 suppression was assessed. Pearson's χ2 test with continuity correction or Fisher's exact test was used to determine statistical significance (alpha = 0.05). Results: Overall prevalence of hrHPV anal infections was 93.3% (152/163). Higher numbers of hrHPV genotypes were detected per sample in the HSIL group compared with less than or Low-grade squamous intraepithelial lesion (≤LSIL) group (p < .001). Proportion of participants infected with HPV33 was higher in the HSIL group (66.7%) than in ≤LSIL group (33.3%, p < .001), as was HPV35 (61.1% vs. 38.9%, p = .001) and HPV56 (56.7% vs. 43.3%, p = .022). HPV33 persistence was highly associated with HSIL (100%; 8/8) compared with ≤LSIL (0%; 0/8) (p < .001). Proportion of HIV-1 suppression (<200 cp/mL) was significantly lower among the HSIL group (80%; 48/60) compared with ≤LSIL group (95.1%; 97/102) (p = .006). Conclusions: Statistically significant associations existed between anal HSIL and HPV33, HPV35, and HPV56 infections, with HPV33 persistence, and with the lack of HIV-1 suppression. These findings emphasize the critical need for genotyping assays that differentiate more than just HPV16, HPV18 and a pool of "other" hrHPV genotypes and that have an intended use with anal specimens. Globally, this highest-risk population would benefit from the 9-valent vaccine to prevent infections and reduce anal cancer risk. Competing Interests: The authors have declared they have no conflicts of interest. (Copyright © 2024, ASCCP.)
Databáze:	MEDLINE
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