Swimming training prevents obesity installation and normalizes hypothalamic expressions of GLP1 and leptin receptors in adult offspring born in small litters.

Autor:	Fischer SV; Department of General Biology, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil., Siqueira BS; Postgraduate Program in Biosciences and Health, Department of Center for Biological and Health Sciences, Universidade Estadual do Oeste do Paraná, Cascavel, PR, Brazil., Cancian CRC; Department of General Biology, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil., Montes EG; Department of General Biology, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil., Vicari VN; Department of General Biology, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil., Svidnicki PV; Department of General Biology, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil., Grassiolli S; Postgraduate Program in Biosciences and Health, Department of Center for Biological and Health Sciences, Universidade Estadual do Oeste do Paraná, Cascavel, PR, Brazil.
Jazyk:	angličtina
Zdroj:	Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2024 Sep 09; Vol. 22, pp. eAO0619. Date of Electronic Publication: 2024 Sep 09 (Print Publication: 2024).
DOI:	10.31744/einstein_journal/2024AO0619
Abstrakt:	Objective: Glucagon-like peptide-1 (GLP1) and leptin (Lep) are afferent signals that regulate energy metabolism. Lactational hypernutrition results in hyperphagia and adiposity in adult life, and these events can be prevented by exercise. We evaluated the effects of swimming training on hypothalamic (GLP1-R) and Lep receptor (Lep-R) gene expressions in lactational hypernutrition-induced obesity. Methods: On the 3rd postnatal day, the litter sizes of lactating dams were adjusted to small litters (SL; 3 pups/dams) or normal litters (NL; 9 pups/dams). After weaning (21 days), NL and SL male rats were randomly distributed to sedentary (Sed) and exercised (Exe) groups. Exercised mice swam (30 min/3 times/week) for 68 days. Food intake and body weight gain were registered. At 92 days, intraperitoneal glucose and insulin tolerance tests were performed and rats were euthanized at 93 days; adipose tissue depots were weighed, and blood counts and plasma biochemical analyses performed. Hypothalamus were isolated to evaluate Lep-R and GLP1-R gene expressions. Results: Small litters sedentary rats presented increased body weight gain, adiposity, insulin sensibility and higher fasting values of glucose and triglycerides, besides higher hypothalamic gene expressions of Lep-R and GLP1-R, compared to NLSed animals. SLExe rats did not develop obesity or metabolic abnormalities and Lep-R and GLP1-R hypothalamic gene expressions were normalized. Conclusion: Lactational hypernutrition induces obesity and metabolic dysfunction in adult life, in association with higher hypothalamic expressions of the Lep-R and GLP1-R genes. Exercise prevented obesity and improved metabolic state in SL overnourished rats, and normalized their hypothalamic Lep-R and GLP1-R gene expressions.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu