Use of etomidate in endotracheal intubations in the emergency room during the COVID-19 pandemic: a randomized clinical trial.

Autor:	Tallo FS; Universidade Federal de São Paulo - São Paulo (SP) - Brazil., Pires-Oliveira M; Centro Universitário UNIME - Lauro de Freitas (BA) - Brazil., Nakai MY; Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP) - Brazil., Nicolau LAD; Universidade Federal do Delta do Parnaíba - Parnaíba (PI) - Brazil., Medeiros JVR; Universidade Federal do Delta do Parnaíba - Parnaíba (PI) - Brazil., Gehrke FS; Centro Universitário Faculdade de Medicina do ABC - Santo André (SP) - Brazil., Taha MO; Universidade Federal de São Paulo - São Paulo (SP) - Brazil., Caricati-Neto A; Universidade Federal de São Paulo - São Paulo (SP) - Brazil., Menezes-Rodrigues FS; Universidade Federal de São Paulo - São Paulo (SP) - Brazil., Abib SCV; Universidade Federal de São Paulo - São Paulo (SP) - Brazil.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2024 Sep 09; Vol. 39, pp. e395724. Date of Electronic Publication: 2024 Sep 09 (Print Publication: 2024).
DOI:	10.1590/acb395724
Abstrakt:	Purpose: Shock, cardiovascular problems, and respiratory failure constitute the main causes of death in patients cared in medical emergency rooms. Patients commonly require orotracheal intubation (OTI), a fact that has been intensified by diseases that generate important and fatal hemodynamic and respiratory problems in the affected patient. Methods: Although etomidate (ETO) is a highly used anesthetic for OTI, its use remains controversial in several scenarios. Some studies refer to an increase in mortality with its use in critically patients, while others do not refer to a difference. Therefore, we evaluated the mortality of patients submitted to OTI in the public hospital of a public federal university, with the use of ETO and other sedative-hypnotic drugs used in the induction of the performance of OTI, with the in-hospital mortality of patients cared in hospital. Results: The results demonstrate that the use of ETO as a hypnotic for OTI in the emergency room is not associated with a significant difference in morbidity or early mortality, within 30 days of hospitalization, compared with other hypnotics. Conclusions: There was no difference in mortality between patients intubated in the emergency department who used ETO and those who used non-ETO hypnotic within 72 hours and 30 days.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu