Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta-Analysis.

Autor: Cui K; Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China., Chen J; Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China., Zhang S; Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China., He C; Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China., Sun S; Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China., Li J; Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China.
Jazyk: angličtina
Zdroj: Clinical transplantation [Clin Transplant] 2024 Sep; Vol. 38 (9), pp. e15449.
DOI: 10.1111/ctr.15449
Abstrakt: Objective and Background: Sinusoidal obstruction syndrome (SOS) is a life-threatening complication in hematopoietic stem cell transplantation (HSCT) patients. However, the related risk factors in pediatric and young adult HSCT recipients remain unclear. Thus, we conducted this meta-analysis to identify potential risk factors for SOS in children and young adults undergoing HSCT.
Method: We acquired related articles through searching PubMed, EMBASE, and the Cochrane Library up to May 31, 2024. We calculated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to identify potential risk factors.
Results: A total of 12 studies with 7644 HSCT recipients were included. Bone marrow transplantation (OR = 1.35, 95% CI: 1.03-1.77, I 2 = 0%), busulfan (BU) (OR = 3.63, 95% CI: 1.78-7.38, I 2 = 70%), and fludarabine (FLU) (OR = 1.55, 95% CI: 1.09-2.21, I 2 = 16%) were risk factors for SOS after HSCT in children and young adults.
Conclusion: Bone marrow transplantation and the use of BU or FLU might be risk factors for SOS after HSCT in children and young adults.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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