The role of Nrf2 in immune cells and inflammatory autoimmune diseases: a comprehensive review.
| Autor: | Xu WD; Department of Evidence-Based Medicine, Southwest Medical University, Luzhou, Sichuan, China., Yang C; Preventive Health Center, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China., Huang AF; Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. |
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| Jazyk: | angličtina |
| Zdroj: | Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2024 Sep; Vol. 28 (9), pp. 789-806. Date of Electronic Publication: 2024 Sep 10. |
| DOI: | 10.1080/14728222.2024.2401518 |
| Abstrakt: | Introduction: Nrf2 regulates mild stress, chronic inflammation, and metabolic changes by regulating different immune cells via downstream signaling. Collection of information about the role of Nrf2 in inflammatory autoimmune diseases will better understand the therapeutic potential of targeting Nrf2 in these diseases. Areas Covered: In this review, we comprehensively discussed biological function of Nrf2 in different immune cells, including Nrf2 preventing oxidative tissue injury, affecting apoptosis of immune cells and inflammatory cytokine production. Moreover, we discussed the role of Nrf2 in the development of inflammatory autoimmune diseases. Expert Opinion: Nrf2 binds to downstream signaling molecules and then provides durable protection against different cellular and organ stress. It has emerged as an important target for inflammatory autoimmune diseases. Development of Nrf2 modulator drugs needs to consider factors such as target specificity, short/long term safety, disease indication identification, and the extent of variation in Nrf2 activity. We carefully discussed the dual role of Nrf2 in some diseases, which helps to better target Nrf2 in the future. |
| Databáze: | MEDLINE |
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