Pituitary adenylate cyclase-activating polypeptide signalling as a therapeutic target in migraine.

Autor: Ashina H; Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Translational Research Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Christensen RH; Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Translational Research Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hay DL; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand., Pradhan AA; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St Louis, St Louis, MO, USA., Hoffmann J; Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Reglodi D; Department of Anatomy, Centre for Neuroscience, University of Pécs Medical School, Pécs, Hungary., Russo AF; Department of Molecular Physiology and Biophysics, University of Iowa, Veterans Affairs Healthcare System, Iowa City, IA, USA.; Department of Neurology, University of Iowa, Veterans Affairs Healthcare System, Iowa City, IA, USA., Ashina M; Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. ashina@dadlnet.dk.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ashina@dadlnet.dk.
Jazyk: angličtina
Zdroj: Nature reviews. Neurology [Nat Rev Neurol] 2024 Nov; Vol. 20 (11), pp. 660-670. Date of Electronic Publication: 2024 Sep 10.
DOI: 10.1038/s41582-024-01011-4
Abstrakt: Migraine is a disabling neurological disorder that affects more than one billion people worldwide. The clinical presentation is characterized by recurrent headache attacks, which are often accompanied by photophobia, phonophobia, nausea and vomiting. Although the pathogenesis of migraine remains incompletely understood, mounting evidence suggests that specific signalling molecules are involved in the initiation and modulation of migraine attacks. These signalling molecules include pituitary adenylate cyclase-activating polypeptide (PACAP), a vasoactive peptide that is known to induce migraine attacks when administered by intravenous infusion to people with migraine. Discoveries linking PACAP to migraine pathogenesis have led to the development of drugs that target PACAP signalling, and a phase II trial has provided evidence that a monoclonal antibody against PACAP is effective for migraine prevention. In this Review, we explore the molecular and cellular mechanisms of PACAP signalling, shedding light on its role in the trigeminovascular system and migraine pathogenesis. We then discuss emerging therapeutic strategies that target PACAP signalling for the treatment of migraine and consider the research needed to translate the current knowledge into a treatment for migraine in the clinic.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
Externí odkaz: