Nitrogen signaling factor triggers a respiration-like gene expression program in fission yeast.

Autor:	Ohsawa S; Friedrich Miescher Institute for Biomedical Research, Fabrikstrasse 24, 4056, Basel, Switzerland., Schwaiger M; Friedrich Miescher Institute for Biomedical Research, Fabrikstrasse 24, 4056, Basel, Switzerland.; Swiss Institute of Bioinformatics, 4056, Basel, Switzerland., Iesmantavicius V; Friedrich Miescher Institute for Biomedical Research, Fabrikstrasse 24, 4056, Basel, Switzerland., Hashimoto R; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan.; Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, 183-8538, Tokyo, Japan., Moriyama H; Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, 183-8538, Tokyo, Japan., Matoba H; Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, 812-8582, Fukuoka, Japan., Hirai G; Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, 812-8582, Fukuoka, Japan.; Catalysis and Integrated Research Group, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan., Sodeoka M; Catalysis and Integrated Research Group, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan., Hashimoto A; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan., Matsuyama A; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan.; Molecular Ligand Target Research Team, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan., Yoshida M; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan.; Office of University Professors, The University of Tokyo, Bunkyo-ku, 113-8657, Tokyo, Japan.; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Bunkyo-ku, 113-8657, Tokyo, Japan., Yashiroda Y; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan. ytyy@riken.jp.; Molecular Ligand Target Research Team, RIKEN Center for Sustainable Resource Science, Wako, 351-0198, Saitama, Japan. ytyy@riken.jp., Bühler M; Friedrich Miescher Institute for Biomedical Research, Fabrikstrasse 24, 4056, Basel, Switzerland. marc.buehler@fmi.ch.; University of Basel, Petersplatz 10, 4003, Basel, Switzerland. marc.buehler@fmi.ch.
Jazyk:	angličtina
Zdroj:	The EMBO journal [EMBO J] 2024 Oct; Vol. 43 (20), pp. 4604-4624. Date of Electronic Publication: 2024 Sep 10.
DOI:	10.1038/s44318-024-00224-z
Abstrakt:	Microbes have evolved intricate communication systems that enable individual cells of a population to send and receive signals in response to changes in their immediate environment. In the fission yeast Schizosaccharomyces pombe, the oxylipin nitrogen signaling factor (NSF) is part of such communication system, which functions to regulate the usage of different nitrogen sources. Yet, the pathways and mechanisms by which NSF acts are poorly understood. Here, we show that NSF physically interacts with the mitochondrial sulfide:quinone oxidoreductase Hmt2 and that it prompts a change from a fermentation- to a respiration-like gene expression program without any change in the carbon source. Our results suggest that NSF activity is not restricted to nitrogen metabolism alone and that it could function as a rheostat to prepare a population of S. pombe cells for an imminent shortage of their preferred nutrients. (© 2024. The Author(s).)
Databáze:	MEDLINE
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