The incidence of acute exacerbation of idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

Autor: Wang Y; National Regional Traditional Chinese Medicine (Lung Disease) Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450046, Henan, People's Republic of China.; The First Clinical College of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, Henan, People's Republic of China., Ji Z; National Regional Traditional Chinese Medicine (Lung Disease) Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450046, Henan, People's Republic of China.; The First Clinical College of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, Henan, People's Republic of China., Xu B; National Regional Traditional Chinese Medicine (Lung Disease) Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450046, Henan, People's Republic of China.; The First Clinical College of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, Henan, People's Republic of China., Li S; National Regional Traditional Chinese Medicine (Lung Disease) Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450046, Henan, People's Republic of China. lisuyun2000@126.com.; Henan University of Traditional Chinese Medicine Respiratory Disease Diagnosis and Treatment and New Drug Research and Development Provincial and Ministry Co-Built Collaborative Innovation Center, Zhengzhou, 450046, Henan, People's Republic of China. lisuyun2000@126.com.; Henan Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Respiratory Diseases, Zhengzhou, 450046, Henan, People's Republic of China. lisuyun2000@126.com., Xie Y; National Regional Traditional Chinese Medicine (Lung Disease) Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450046, Henan, People's Republic of China. xieyanghn@163.com.; Henan University of Traditional Chinese Medicine Respiratory Disease Diagnosis and Treatment and New Drug Research and Development Provincial and Ministry Co-Built Collaborative Innovation Center, Zhengzhou, 450046, Henan, People's Republic of China. xieyanghn@163.com.; Henan Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Respiratory Diseases, Zhengzhou, 450046, Henan, People's Republic of China. xieyanghn@163.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 10; Vol. 14 (1), pp. 21080. Date of Electronic Publication: 2024 Sep 10.
DOI: 10.1038/s41598-024-71845-x
Abstrakt: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with a high incidence of acute exacerbation and an increasing mortality rate. Currently, treatment methods and effects are limited. Therefore, we conducted a meta-analysis of the incidence of acute exacerbation in patients with IPF, hoping to provide reference for the prevention and management of IPF. We systematically searched the PubMed, Embase, Cochrane Library and Web of Science databases. From the creation of the database to the cohort study on April 3, 2023, we collected studies on the incidence of acute exacerbation of IPF patients, and used Stata software (version 16.0) for meta analysis. We used the Newcastle Ottawa Quality Assessment Scale (NOS) to assess the risk of bias for each study. We calculated the incidence of acute exacerbation in IPF patients and analyzed the risk factors for acute exacerbation in IPF patients and prognostic factors for overall survival from the initial IPF diagnosis. A total of ten cohort studies on the incidence of AE-IPF were included, including 11,855 IPF patients. The results showed that the incidence of acute exacerbation within one year was 9%; the incidence of acute exacerbation within 2 years is 13%; the incidence of acute exacerbation within 3 years is 19%; the incidence of acute exacerbation within 4 years is 11%. In addition, one study reported an acute exacerbation rate of 1.9% within 30 days. The incidence of acute exacerbation within ten years reported in one study was 9.8%. Mura et al.'s article included a retrospective cohort study and a prospective cohort study. The prospective cohort study showed that the incidence of acute exacerbation within 3 years was 18.6%, similar to the results of the retrospective cohort study meta-analysis. Our system evaluation and meta-analysis results show that the incidence of AE-IPF is relatively high. Therefore, sufficient attention should be paid to the research results, including the management and prevention of the disease, in order to reduce the risk of AE.Trial registration: PROSPERO, identifier CRD42022341323.
(© 2024. The Author(s).)
Databáze: MEDLINE
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