Serum Selenium Levels and Lipid Profile: A Systematic Review and Meta-analysis of Observational Studies.

Autor: Mazaheri-Tehrani S; Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. s.mazaheri@edc.mui.ac.ir.; Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. s.mazaheri@edc.mui.ac.ir.; Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. s.mazaheri@edc.mui.ac.ir., Abhari AP; Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. amirparsaabhari@gmail.com., Ostadsharif N; Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran., Shekarian A; Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Vali M; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Saffari E; Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Anaraki KT; Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran., Haghighatpanah MA; Department of Cardiovascular Surgery, Chamran Heart Center, Isfahan University of Medical Sciences, Isfahan, Iran., Fakhrolmobasheri M; Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran., Kieliszek M; Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159C, 02-776, Warsaw, Poland. marek-kieliszek@wp.pl.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Sep 11. Date of Electronic Publication: 2024 Sep 11.
DOI: 10.1007/s12011-024-04365-4
Abstrakt: Selenium is a trace element with pivotal roles in metabolic processes. Studies suggested that selenium deficiency could lead to impaired lipid profiles. However, inconsistent results have been reported regarding the association between serum selenium concentrations and lipid profile (triglycerides, LDL, HDL, VLDL, and total cholesterol). Thus, we aimed to review the correlation between them. A systematic literature search was conducted in PubMed, Embase, Web of Science, Scopus, and Google Scholar until 31 December 2023. The relevant correlation coefficients were used as desired effect sizes to assess the correlation between selenium level and lipid profile. Among 8291 records found in the primary search, 47 and 34 articles were included in the systematic review and meta-analysis, respectively. All included studies were observational investigations and had acceptable quality. Our results failed to reach strong evidence supporting the correlation between serum selenium level and lipid profiles, except for HDL, which showed a weak correlation among both adults (r = 0.1 [0.03:0.17]; I 2  = 71%) and pediatrics (r = 0.08 [0.03:0.14]; I 2  = 38%). Subgroup analyses based on gender did not reveal a significant or strong correlation with selenium levels (except for total cholesterol in males (r = 0.12 [0.01:0.22]; I 2  = 52%)). The results did not change after the sensitivity analysis. Although some previous studies have suggested that selenium deficiency could lead to impaired lipid profile, the findings of this study indicate no strong correlation between serum selenium levels and lipid profile.
(© 2024. The Author(s).)
Databáze: MEDLINE
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