Vein of galen malformations: for patients and caregivers.

Autor: Aydin S; School of Medicine, Koc University, Istanbul, Turkey., Darko K; Department of Neurosurgery, Korle Bu Teaching Hospital, Accra, Ghana., Detchou D; Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA. Donalddetchou@gmail.com., Barrie U; Department of Neurosurgery, New York University Grossman School of Medicine, New York City, NYC, USA.
Jazyk: angličtina
Zdroj: Neurosurgical review [Neurosurg Rev] 2024 Sep 11; Vol. 47 (1), pp. 587. Date of Electronic Publication: 2024 Sep 11.
DOI: 10.1007/s10143-024-02851-w
Abstrakt: Vein of Galen malformations (VOGMs), also known as Vein of Galen Aneurysmal Malformations (VGAMs), are rare and complex cerebrovascular anomalies that pose significant diagnostic and therapeutic challenges. These malformations result from abnormal arteriovenous shunts during embryonic development, leading to a range of severe clinical manifestations, including high-output cardiac failure and hydrocephalus. Advances in prenatal imaging, particularly fetal MRI, have improved early detection, allowing for timely intervention. Endovascular techniques, especially transarterial embolization, have become the primary treatment modality, often preferred over surgical approaches due to their effectiveness and lower risk. However, challenges remain, particularly in managing these malformations in neonates and infants, where the risk of complications is high. Gamma Knife radiosurgery offers a non-invasive alternative for select cases, though its effects are gradual and may carry delayed risks. Despite advancements, the management of VOGMs continues to require a multidisciplinary approach, with ongoing research focused on improving outcomes through a better understanding of the genetic and molecular underpinnings of the disease. Future directions include the integration of genetic studies into clinical practice and the refinement of treatment strategies to optimize outcomes for this complex condition.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: