Automatic retinal image analysis methods using colour fundus images for screening glaucomatous optic neuropathy.

Autor:	Shi C; Center for Clinical Research and Biostatistics, Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China., Lee J; Center for Clinical Research and Biostatistics, Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Shi D; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China., Wang G; Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Ophthalmology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, People's Republic of China., Yuan F; Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China., Zee BC; Center for Clinical Research and Biostatistics, Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China bzee@cuhk.edu.hk.
Jazyk:	angličtina
Zdroj:	BMJ open ophthalmology [BMJ Open Ophthalmol] 2024 Sep 10; Vol. 9 (1). Date of Electronic Publication: 2024 Sep 10.
DOI:	10.1136/bmjophth-2023-001594
Abstrakt:	Objectives: Train an automatic retinal image analysis (ARIA) method to screen glaucomatous optic neuropathy (GON) on non-mydriatic retinal images labelled with the additional results of optical coherence tomography (OCT) and assess different models for the GON classification. Methods: All the images were obtained from the hospital for training and 10-fold cross-validation. Two methods were used to improve the classification performance: (1) using images labelled with the additional results of OCT as the reference standard and (2) generating models using retinal features from the entire images, the region of interest (ROI) of the optic disc, and the ROI of the macula, and the combination of all the features. Results: Overall, we collected 1338 images with paired OCT scans. In 10-fold validation, ARIA achieved sensitivities of 92.2 %, 92.7% and 85.7%, specificities of 88.8%, 86.7% and 80.2% and accuracies of 90.6%, 89.9% and 83.1% using the retinal features from the entire images, the ROI of the optic disc and the ROI of the macula, respectively. We found the model combining all the features has the best classification performance and obtained a sensitivity of 92.5%, a specificity of 92.1% and an accuracy of 92.4%, which is significantly different from other models (p<0.001). Conclusion: We used two methods to improve the classification performance and found the best model to detect glaucoma on colour fundus retinal images. It can become a cost-effective and relatively more accurate glaucoma screening tool than conventional methods. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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