Scission-Enhanced Molecular Imaging (SEMI).

Autor: Quintana JM; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Carlson JCT; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Scott E; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States., Ng TSC; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Miller MA; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Weissleder R; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.; Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, United States.
Jazyk: angličtina
Zdroj: Bioconjugate chemistry [Bioconjug Chem] 2024 Sep 10. Date of Electronic Publication: 2024 Sep 10.
DOI: 10.1021/acs.bioconjchem.4c00337
Abstrakt: Positron emission tomography (PET) imaging methods have advanced our understanding of human biology, while targeted radiotherapeutic drug treatments are now routinely used clinically. The field is expected to grow considerably based on an expanding repertoire of available affinity ligands, radionuclides, conjugation chemistries, and their FDA approvals. With this increasing use, strategies for dose reduction have become of high interest to protect patients from unnecessary and off-target toxicity. Here, we describe a simple and powerful method, scission-enhanced molecular imaging (SEMI). The technique allows for rapid corporeal elimination of radionuclides once imaging or theranostic treatment is completed and relies on "click-to-release" bioorthogonal linkers.
Databáze: MEDLINE
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