Millimeter wave radiation to measure blood flow in healthy human subjects.

Autor:	Nelson JL; William B Burnsed Jr Department of Mechanical, Aerospace, and Biomedical Engineering, University of South Alabama, Mobile, AL, United States of America., Cobb C; William B Burnsed Jr Department of Mechanical, Aerospace, and Biomedical Engineering, University of South Alabama, Mobile, AL, United States of America., Keller JL; Department of Health, Kinesiology, and Sport, University of South Alabama, Mobile, AL, United States of America.; Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL, United States of America., Traylor MK; Department of Health, Kinesiology, and Sport, University of South Alabama, Mobile, AL, United States of America., Nelson DA; William B Burnsed Jr Department of Mechanical, Aerospace, and Biomedical Engineering, University of South Alabama, Mobile, AL, United States of America., Francis CM; Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL, United States of America.
Jazyk:	angličtina
Zdroj:	Physiological measurement [Physiol Meas] 2024 Sep 19; Vol. 45 (9). Date of Electronic Publication: 2024 Sep 19.
DOI:	10.1088/1361-6579/ad7931
Abstrakt:	Objective. Peripheral Artery Disease (PAD) is a progressive cardiovascular condition affecting 8-10 million adults in the United States. PAD elevates the risk of cardiovascular events, but up to 50% of people with PAD are asymptomatic and undiagnosed. In this study, we tested the ability of a device, REFLO (Rapid Electromagnetic FLOw), to identify low blood flow using electromagnetic radiation and dynamic thermography toward a non-invasive PAD diagnostic. Approach. During REFLO radio frequency (RF) irradiation, the rate of temperature increase is a function of the rate of energy absorption and blood flow to the irradiated tissue. For a given rate of RF energy absorption, a slow rate of temperature increase implies a large blood flow rate to the tissue. This is due to the cooling effect of the blood. Post-irradiation, a slow rate of temperature decrease is associated with a low rate of blood flow to the tissue. Here, we performed two cohorts of controlled flow experiments on human calves during baseline, occluded, and post-occluded conditions. Nonlinear regression was used to fit temperature data and obtain the rate constant, which was used as a metric for blood flow. Main results. In the pilot study, ( N = 7) REFLO distinguished between baseline and post-occlusion during the irradiation phase, and between baseline and occlusion in the post-irradiation phase. In the reliability study, ( N = 5 with 3 visits each), two-way ANOVA revealed that flow and subject significantly affected skin heating and cooling rates, while visit did not. Significance. Results suggest that MMW irradiation can be used to distinguish between blood flow rates in humans. Utilizing the rate of skin cooling rather than heating is more consistent for distinguishing flow. Future modifications and clinical testing will aim to improve REFLO's ability to distinguish between flow rates and evaluate its ability to accurately identify PAD. (© 2024 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.)
Databáze:	MEDLINE
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