Spatiotemporal resonance in mouse primary visual cortex.

Autor:	Gulbinaite R; Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands. Electronic address: rasa.gulbinaite@gmail.com., Nazari M; Canadian Centre for Behavioral Neuroscience, University of Lethbridge Lethbridge, AB T1K 3M4, Canada., Rule ME; School of Engineering Mathematics and Technology, University of Bristol, Queen's Building, Bristol BS8 1TR, UK., Bermudez-Contreras EJ; Canadian Centre for Behavioral Neuroscience, University of Lethbridge Lethbridge, AB T1K 3M4, Canada., Cohen MX; Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6525 EN Nijmegen, the Netherlands., Mohajerani MH; Canadian Centre for Behavioral Neuroscience, University of Lethbridge Lethbridge, AB T1K 3M4, Canada; Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, Montréal, QC H4H 1R3, Canada., Heimel JA; Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2024 Sep 23; Vol. 34 (18), pp. 4184-4196.e7. Date of Electronic Publication: 2024 Sep 09.
DOI:	10.1016/j.cub.2024.07.091
Abstrakt:	Human primary visual cortex (V1) responds more strongly, or resonates, when exposed to ∼10, ∼15-20, and ∼40-50 Hz rhythmic flickering light. Full-field flicker also evokes the perception of hallucinatory geometric patterns, which mathematical models explain as standing-wave formations emerging from periodic forcing at resonant frequencies of the simulated neural network. However, empirical evidence for such flicker-induced standing waves in the visual cortex was missing. We recorded cortical responses to flicker in awake mice using high-spatial-resolution widefield imaging in combination with high-temporal-resolution glutamate-sensing fluorescent reporter (iGluSnFR). The temporal frequency tuning curves in the mouse V1 were similar to those observed in humans, showing a banded structure with multiple resonance peaks (8, 15, and 33 Hz). Spatially, all flicker frequencies evoked responses in V1 corresponding to retinotopic stimulus location, but some evoked additional peaks. These flicker-induced cortical patterns displayed standing-wave characteristics and matched linear wave equation solutions in an area restricted to the visual cortex. Taken together, the interaction of periodic traveling waves with cortical area boundaries leads to spatiotemporal activity patterns that may affect perception. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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