Epigenetic reprogramming enables NF1A/B oncogenic role in SHH medulloblastoma.
| Autor: | Badodi S; Brain Tumour Research Centre, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. Electronic address: s.badodi@qmul.ac.uk., Marino S; Brain Tumour Research Centre, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK; Barts Brain Tumour Centre, Faculty of Medicine and Dentistry, Queen Mary University of London and Barts Health NHS Trust, London, UK. Electronic address: s.marino@qmul.ac.uk. |
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| Jazyk: | angličtina |
| Zdroj: | Developmental cell [Dev Cell] 2024 Sep 09; Vol. 59 (17), pp. 2275-2276. |
| DOI: | 10.1016/j.devcel.2024.07.002 |
| Abstrakt: | In this issue of Developmental Cell, Shiraishi et al. investigate the epigenetic changes occurring during the formation of SHH medulloblastoma and show that an epigenomic shift renders Nuclear Factor I family of transcription factors oncogenic. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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