Phycocyanin attenuates skeletal muscle damage and fatigue via modulation of Nrf2 and IRS-1/AKT/mTOR pathway in exercise-induced oxidative stress in rats.

Autor: Puengpan S; Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand., Phetrungnapha A; Department of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand., Sattayakawee S; Thailand Science Research and Innovation (TSRI), Bangkok, Thailand., Tunsophon S; Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Sep 10; Vol. 19 (9), pp. e0310138. Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0310138
Abstrakt: Prolonged strenuous exercise induces oxidative stress, leading to oxidative damage, skeletal muscle fatigue, and reduced exercise performance. The body compensates for oxidative stress through antioxidant actions, while related enzymes alone may not overcome excessive oxidative stress during prolonged strenuous exercise. Phycocyanin is an important antioxidant supplement derived from blue-green algae, which may be helpful in this type of situation. This study determined the effects of phycocyanin on exercise performance from prolonged strenuous exercise. Forty Sprague Dawley male rats were divided into 5 groups (n = 8 /group); Control group (C), Exercise group (E), and Exercise with supplement groups receiving low dose (Phycocyanin = 100 mg/kg BW; ELP) and high dose (Phycocyanin = 200 mg/kg BW; EHP) or vitamin C (Vitamin C = 200 mg/kg BW; VC). Phycocyanin was found to decrease oxidative damage markers, muscle fatigue, and muscle atrophy through the activated AKT/mTOR pathway. This was also found to have greater increases in antioxidants via Nrf2 signaling and increases ATP synthesis, GLUT4 transporters, and insulin signaling due to increased IRS-1/AKT signaling. In conclusion, phycocyanin was found to reduce oxidative damage and muscle atrophy, including an increase in insulin signaling in skeletal muscles leading to increased exercise performance in rats.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Puengpan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje