Where the "ruber" Meets the Road: Using the Genome of the Red Diamond Rattlesnake to Unravel the Evolutionary Processes Driving Venom Evolution.

Autor:	Hirst SR; Department of Integrative Biology, University of South Florida, Tampa, FL, USA., Rautsaw RM; Department of Integrative Biology, University of South Florida, Tampa, FL, USA.; School of Biological Sciences, Washington State University, Pullman, WA, USA., VanHorn CM; Department of Integrative Biology, University of South Florida, Tampa, FL, USA., Beer MA; School of Biological Sciences, Washington State University, Pullman, WA, USA., McDonald PJ; Department of Integrative Biology, University of South Florida, Tampa, FL, USA., Rosales García RA; Biological Sciences Department, Clemson University, Clemson, SC, USA., Rodriguez Lopez B; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Durango, Mexico., Rubio Rincón A; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Durango, Mexico., Franz Chávez H; Herp.MX©, Colima, Mexico., Vásquez-Cruz V; Facultad de Ciencias Biológicas y Agropecuarias, Universidad Veracruzana, Veracruz, Mexico.; PIMVS Herpetario Palancoatl, Veracruz, Mexico., Kelly Hernández A; PIMVS Herpetario Palancoatl, Veracruz, Mexico., Storfer A; School of Biological Sciences, Washington State University, Pullman, WA, USA., Borja M; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Durango, Mexico., Castañeda-Gaytán G; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Durango, Mexico., Frandsen PB; Department of Plant and Wildlife Sciences, Brigham Young University, Provo, UT, USA., Parkinson CL; Biological Sciences Department, Clemson University, Clemson, SC, USA., Strickland JL; Department of Biology, University of South Alabama, Mobile, AL, USA., Margres MJ; Department of Integrative Biology, University of South Florida, Tampa, FL, USA.
Jazyk:	angličtina
Zdroj:	Genome biology and evolution [Genome Biol Evol] 2024 Sep 03; Vol. 16 (9).
DOI:	10.1093/gbe/evae198
Abstrakt:	Understanding the proximate and ultimate causes of phenotypic variation is fundamental in evolutionary research, as such variation provides the substrate for selection to act upon. Although trait variation can arise due to selection, the importance of neutral processes is sometimes understudied. We presented the first reference-quality genome of the Red Diamond Rattlesnake (Crotalus ruber) and used range-wide 'omic data to estimate the degree to which neutral and adaptive evolutionary processes shaped venom evolution. We characterized population structure and found substantial genetic differentiation across two populations, each with distinct demographic histories. We identified significant differentiation in venom expression across age classes with substantially reduced but discernible differentiation across populations. We then used conditional redundancy analysis to test whether venom expression variation was best predicted by neutral divergence patterns or geographically variable (a)biotic factors. Snake size was the most significant predictor of venom variation, with environment, prey availability, and neutral sequence variation also identified as significant factors, though to a lesser degree. By directly including neutrality in the model, our results confidently highlight the predominant, yet not singular, role of life history in shaping venom evolution. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
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