| Autor: |
Pulgar-Sánchez M; Institute of Pharmacology & Toxicology, University Hospital Bonn, Bonn, 53127, Germany., Chamorro K; School of Mathematics & Computational Sciences, Universidad Yachay Tech, Urcuquí, 100115, Ecuador., Casella C; Department of Chemical, Environmental & Bionutritional Engineering, Universidad de Oviedo, Oviedo, 33006, Spain., Ballaz SJ; Medical School, Universidad Espíritu Santo, Samborondón, 0901952, Ecuador. |
| Abstrakt: |
Aim: A laboratory finding in critically ill COVID-19 patients is blood academia (pH <7.35). We investigated its cause in connection with the admission baseline blood pH homeostasis. Patients & methods: We retrospectively monitored the baseline blood pH homeostasis of 1215 COVID-19 patients who were admitted with pneumonia using data-driven knowledge. Two categories of patients were identified: non-survivors (107) and survivors (1108). Results: Non-survivors showed greater levels of lactate and lower blood pH, saturation, and partial pressure of oxygen than survivors. A bivariate Spearman's correlation matrix showed that the [HCO 3 - ]/pCO 2 and pCO 2 of non-survivors exhibited an unmatched connection, but not in the survivor group. When comparing non-survivors to survivors, the dendrograms derived from the bivariate comparison matrix showed differences in gasometry parameters like blood pH, [HCO 3 - ]/pCO 2 ratio, anion gap and pO 2 . Conclusion: The little variations in the gasometry readings between survivors and non-survivors upon admission suggested abnormal changes in the complementary renal and respiratory systems that bring blood pH back to normal. In advanced COVID-19, modest blood acid-base imbalances could become blood acidemia if these compensatory strategies were overused. Data-driven monitoring of acid-base parameters may help predict abnormal blood pH and the advancement of metabolic acidemia before it is too late. |
