Estimated Health and Economic Outcomes of Racial and Ethnic Tuberculosis Disparities in US-Born Persons.

Autor:	Swartwood NA; Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Li Y; Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Regan M; Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Marks SM; Division of Tuberculosis Elimination, US Centers for Disease Control and Prevention, Atlanta, Georgia., Barham T; Office of Health Equity, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, US Centers for Disease Control and Prevention, Atlanta, Georgia., Beeler Asay GR; Division of Tuberculosis Elimination, US Centers for Disease Control and Prevention, Atlanta, Georgia., Cohen T; Yale School of Public Health, New Haven, Connecticut., Hill AN; Division of Tuberculosis Elimination, US Centers for Disease Control and Prevention, Atlanta, Georgia., Horsburgh CR Jr; Boston University Schools of Public Health and Medicine, Departments of Epidemiology, Biostatistics, Global Health and Medicine, Boston, Massachusetts., Khan AD; Division of Tuberculosis Elimination, US Centers for Disease Control and Prevention, Atlanta, Georgia., McCree DH; Office of Health Equity, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, US Centers for Disease Control and Prevention, Atlanta, Georgia., Myles RL; Office of Health Equity, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, US Centers for Disease Control and Prevention, Atlanta, Georgia., Salomon JA; Center for Health Policy, Stanford University, Stanford, California., Self JL; Division of Tuberculosis Elimination, US Centers for Disease Control and Prevention, Atlanta, Georgia., Menzies NA; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Jazyk:	angličtina
Zdroj:	JAMA network open [JAMA Netw Open] 2024 Sep 03; Vol. 7 (9), pp. e2431988. Date of Electronic Publication: 2024 Sep 03.
DOI:	10.1001/jamanetworkopen.2024.31988
Abstrakt:	Importance: Despite significant progress made toward tuberculosis (TB) elimination, racial and ethnic disparities persist in TB incidence and case-fatality rates in the US. Objective: To estimate the health outcomes and economic cost of TB disparities among US-born persons from 2023 to 2035. Design, Setting, and Participants: Generalized additive regression models projecting trends in TB incidence and case-fatality rates from 2023 to 2035 were fit based on national TB surveillance data for 2010 to 2019 in the 50 US states and the District of Columbia among US-born persons. This baseline scenario was compared with alternative scenarios in which racial and ethnic disparities in age- and sex-adjusted incidence and case-fatality rates were eliminated by setting rates for each race and ethnicity to goal values. Additional scenarios were created examining the potential outcomes of delayed reduction of racial and ethnic disparities. The potential benefits of eliminating disparities from differences between baseline and alternative scenario outcomes were quantified. Data were analyzed from January 2010 to December 2019. Exposures: Non-Hispanic American Indian or Alaska Native, non-Hispanic Asian, non-Hispanic Black, Hispanic, non-Hispanic Native Hawaiian or Other Pacific Islander, or non-Hispanic White race and ethnicity. Main Outcomes and Measures: TB cases and deaths averted, quality-adjusted life years gained, and associated costs from a societal perspective. Results: The study included 31 811 persons with reported TB from 2010 to 2019 (mean [SD] age, 47 [24] years; 20 504 [64%] male; 1179 [4%] American Indian or Alaska Native persons; 1332 [4%] Asian persons; 12 152 [38%] Black persons; 6595 [21%] Hispanic persons; 299 [1%] Native Hawaiian or Other Pacific Islander persons; and 10 254 [32%] White persons). There were 3722 persons with a reported TB death. Persistent racial and ethnic disparities were associated with an estimated 11 901 of 26 203 TB cases among US-born persons (45%; 95% uncertainty interval [UI], 44%-47%), 1421 of 3264 TB deaths among US-born persons (44%; 95% UI, 39%-48%), and an economic cost of $914 (95% UI, $675-$1147) million from 2023 to 2035. Delayed goal attainment reduced the estimated avertable TB outcomes by 505 (95% UI, 495-518) TB cases, 55 (95% UI, 51-59) TB deaths, and $32 (95% UI, $24-$40) million in societal costs annually. Conclusions and Relevance: In this modeling study of racial and ethnic disparities of TB, these disparities were associated with substantial future health and economic outcomes of TB among US-born persons without interventions beyond current efforts. Actions to eliminate disparities may reduce the excess TB burden among these persons and may contribute to accelerating TB elimination within the US.
Databáze:	MEDLINE
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