Takotsubo syndrome in a Sardinian amyotrophic lateral sclerosis cohort.

Autor: Maccabeo A; Department of Medical Sciences and Public Health, Institute of Neurology, Policlinico Universitario di Monserrato, University of Cagliari, 09042, Cagliari, Italy. alessandramaccabeo@outlook.it., Pateri MI; Department of Medical Sciences and Public Health, Institute of Neurology, Policlinico Universitario di Monserrato, University of Cagliari, 09042, Cagliari, Italy., Pili F; Neurology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy., Pilotto S; Department of Medical Sciences and Public Health, Institute of Neurology, Policlinico Universitario di Monserrato, University of Cagliari, 09042, Cagliari, Italy., Pierri V; Department of Medical Sciences and Public Health, Institute of Neurology, Policlinico Universitario di Monserrato, University of Cagliari, 09042, Cagliari, Italy., Muroni A; Neurology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy., Ercoli T; Department of Neurology, University of Sassari, Viale S. Pietro 10, 07100, Sassari, Italy., Montisci R; Cardiology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy., Marchetti MF; Cardiology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy., Martis A; Department of Medical Sciences and Public Health, Institute of Cardiology, University of Cagliari, Cagliari, Italy., Fazzini L; Department of Medical Sciences and Public Health, Institute of Cardiology, University of Cagliari, Cagliari, Italy., Defazio G; Department of Translational Biomedicine and Neurosciences, University of Bari 'Aldo Moro', Bari, Italy., Puligheddu M; Neurology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy., Borghero G; Neurology Unit, AOU Cagliari, Hospital D. Casula Monserrato, Cagliari, Italy.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2024 Dec; Vol. 271 (12), pp. 7489-7493. Date of Electronic Publication: 2024 Sep 10.
DOI: 10.1007/s00415-024-12681-x
Abstrakt: Introduction: Amyotrophic lateral sclerosis (ALS) is known to be associated with varying degrees of autonomic and cardiovascular dysfunction. Recent case reports showed that ALS may be linked to Takotsubo syndrome (TTS). We assessed the frequency of TTS in an incident ALS cohort from Sardinia, Italy, and investigated the relationship of TTS with ALS course.
Methods: We retrospectively examined a 10-year (2010-2019) incident cohort of ALS patients of Sardinian ancestry, reported TTS frequency and patients' clinical characteristics. Following, we checked for TTS among patients with ALS onset after 2019 and focused on the same features as for the incident cohort.
Results: Our incident cohort included 344 ALS patients and 5 of them (1.45%) developed TTS. All were female and their median onset age was 71.5 years (IQR 62.75-77). Two patients had spinal and three bulbar onset, though all patients had bulbar involvement and were at an advanced stage of disease (ALSFRS ≤ 25, King's ≥ 3) at TTS diagnosis. We identified a potential TTS trigger in three patients (hospitalization for PEG placement, pneumonia). Among patients who had ALS onset after 2019, we identified a further TTS case and described it.
Conclusion: TTS is not a rare condition in ALS. Female sex, bulbar involvement, and later age of disease onset may be important risk factors for developing this cardiac condition and a physical or psychological trigger is often observed. Despite autonomic dysfunction in ALS has been already demonstrated, the precise physiopathological mechanism underlying TTS needs to be further clarified.
Competing Interests: Declarations. Conflicts of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Ethical approval: The study was approved by the local Institutional Review Board and conducted in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
(© 2024. The Author(s).)
Databáze: MEDLINE
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