Positive-strand RNA virus replication organelles at a glance.
| Autor: | Stancheva VG; Sir William Dunn School of Pathology , University of Oxford, South Parks Road, Oxford, OX1 3RE, UK., Sanyal S; Sir William Dunn School of Pathology , University of Oxford, South Parks Road, Oxford, OX1 3RE, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cell science [J Cell Sci] 2024 Sep 01; Vol. 137 (17). Date of Electronic Publication: 2024 Sep 10. |
| DOI: | 10.1242/jcs.262164 |
| Abstrakt: | Membrane-bound replication organelles (ROs) are a unifying feature among diverse positive-strand RNA viruses. These compartments, formed as alterations of various host organelles, provide a protective niche for viral genome replication. Some ROs are characterised by a membrane-spanning pore formed by viral proteins. The RO membrane separates the interior from immune sensors in the cytoplasm. Recent advances in imaging techniques have revealed striking diversity in RO morphology and origin across virus families. Nevertheless, ROs share core features such as interactions with host proteins for their biogenesis and for lipid and energy transfer. The restructuring of host membranes for RO biogenesis and maintenance requires coordinated action of viral and host factors, including membrane-bending proteins, lipid-modifying enzymes and tethers for interorganellar contacts. In this Cell Science at a Glance article and the accompanying poster, we highlight ROs as a universal feature of positive-strand RNA viruses reliant on virus-host interplay, and we discuss ROs in the context of extensive research focusing on their potential as promising targets for antiviral therapies and their role as models for understanding fundamental principles of cell biology. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2024. Published by The Company of Biologists Ltd.) |
| Databáze: | MEDLINE |
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