Objective quantification of posterior capsule opacification using swept-source AS-OCT.

Autor:	Tao S; From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China., Liang F, Fan S, Wang M, Zhang Y, Liu X, He C
Jazyk:	angličtina
Zdroj:	Journal of cataract and refractive surgery [J Cataract Refract Surg] 2025 Jan 01; Vol. 51 (1), pp. 3-8.
DOI:	10.1097/j.jcrs.0000000000001546
Abstrakt:	Purpose: To objectively quantify posterior capsule opacification (PCO) using swept-source anterior segment optical coherence tomography (SS-AS-OCT) in pseudophakic eyes. Setting: Zhongshan Ophthalmic Center, Guangzhou, China. Design: Prospective cross-sectional study. Methods: 180 eyes with PCO (37 multifocal intraocular lenses [mfIOLs] and 143 monofocal intraocular lenses [moIOLs]) were enrolled. The PCO irregular degree (PID), defined to evaluate the surface irregularity of PCO, the average and maximum thickness of PCO (AT-PCO, MT-PCO) were applied to quantify PCO based on SS-AS-OCT (CASIA2) images. Corrected distance visual acuity (CDVA), higher-order aberrations (HOAs), modulation transfer function, and Strehl ratio were recorded. The associations between SS-AS-OCT parameters and visual function parameters were assessed by Spearman correlation analysis. Results: PID, AT-PCO, and MT-PCO showed significant correlations with CDVA, Strehl ratio, and HOAs (CDVA: r = 0.702, 0.741, and 0.736; Strehl ratio: r = -0.746, -0.719, and -0.740; HOAs: r = 0.762, 0.734, and 0.752). The correlations of these 3 parameters with Strehl ratio and HOAs were significantly higher than those of clinical PCO grading with Strehl ratio and HOAs (all P < .05). Particularly, PID demonstrated notable correlations with Strehl ratio and HOAs. In addition, patients with mfIOLs presented worse Strehl ratio and HOAs than those with moIOLs after matching age, PID, AT-PCO, and MT-PCO. Conclusions: This study provides a new method for objectively quantifying PCO using successive cross-sectional SS-AS-OCT images. AT-PCO, MT-PCO, and PID are presented as new indicators to document PCO severity, with PID offering a unique perspective by considering the irregularity aspect of PCO. (Copyright © 2024 Published by Wolters Kluwer on behalf of ASCRS and ESCRS.)
Databáze:	MEDLINE
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