A consultation and work-up diagnosis protocol for a multicancer early detection test: a case series study.

Autor:	Dang Nguyen LH; Gene Solutions, Ho Chi Minh, Vietnam., Tieu BL; Gene Solutions, Ho Chi Minh, Vietnam., Nguyen TT; Gene Solutions, Ho Chi Minh, Vietnam., Ha NP; Gene Solutions, Ho Chi Minh, Vietnam., Huong Nguyen GT; Gene Solutions, Ho Chi Minh, Vietnam., Hanh Nguyen TH; Gene Solutions, Ho Chi Minh, Vietnam., Le VH; National Cancer Hospital, Hanoi, Vietnam., Bui VQ; Hanoi Oncology Hospital, Hanoi, Vietnam., Nguyen LH; Hanoi Medical University, Hanoi, Vietnam., Pham NH; Hue Central Hospital, Hue, Vietnam., Phan TH; Medic Medical Center, Ho Chi Minh, Vietnam., Nguyen HT; University Medical Center HCM, Ho Chi Minh Vietnam., Tran VS; People's Hospital 115, Ho Chi Minh, Vietnam., Bui CV; Xuyen A General Hospital, Ho Chi Minh, Vietnam., Vo VK; Cantho Oncology Hospital, Can Tho, Vietnam., Nhan Nguyen PT; Danang Oncology Hospital, Da Nang, Vietnam., Phuoc Dang HH; Dongnai General Hospital, Dong Nai, Vietnam., Pham VD; Thong Nhat Dongnai General Hospital, Dong Nai, Vietnam., Cao VT; Le Van Thinh Hospital, Ho Chi Minh, Vietnam., Phan NM; Gene Solutions, Ho Chi Minh, Vietnam., Nguyen VT; National Cancer Hospital, Hanoi, Vietnam., Quyen Le TL; Hanoi Oncology Hospital, Hanoi, Vietnam., Luong TL; Hanoi Medical University, Hanoi, Vietnam., Phuong Doan TK; Hanoi Medical University, Hanoi, Vietnam., Phan CD; Hue Central Hospital, Hue, Vietnam., Nguyen TX; Hue Central Hospital, Hue, Vietnam., Pham NT; Hue Central Hospital, Hue, Vietnam., Nguyen BT; Medic Medical Center, Ho Chi Minh, Vietnam., Thuy Pham TT; Medic Medical Center, Ho Chi Minh, Vietnam., Le HL; Medic Medical Center, Ho Chi Minh, Vietnam., Truong CT; Medic Medical Center, Ho Chi Minh, Vietnam., Jasmine TX; Medic Medical Center, Ho Chi Minh, Vietnam., Le MC; University Medical Center HCM, Ho Chi Minh Vietnam., Phan VB; People's Hospital 115, Ho Chi Minh, Vietnam., Truong QB; University Medical Center HCM, Ho Chi Minh Vietnam., Ly Tran TH; Cantho Oncology Hospital, Can Tho, Vietnam., Huynh MT; Cantho Oncology Hospital, Can Tho, Vietnam., Tran TQ; Danang Oncology Hospital, Da Nang, Vietnam., Nguyen ST; Thong Nhat Dongnai General Hospital, Dong Nai, Vietnam., Tran V; Thong Nhat Dongnai General Hospital, Dong Nai, Vietnam., Tran VK; Le Van Thinh Hospital, Ho Chi Minh, Vietnam., Nguyen HN; Gene Solutions, Ho Chi Minh, Vietnam., Phan TV; Gene Solutions, Ho Chi Minh, Vietnam., Do TT; Medical Genetics Institute, Ho Chi Minh, Vietnam., Truong DK; Medical Genetics Institute, Ho Chi Minh, Vietnam., Giang H; Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam., Nguyen HN; Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam., Phan MD; Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam., Tran LS; Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam., Tang HS; Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam., Nguyen DS; Gene Solutions, Ho Chi Minh, Vietnam.; Medical Genetics Institute, Ho Chi Minh, Vietnam.
Jazyk:	angličtina
Zdroj:	Future science OA [Future Sci OA] 2024 Dec 31; Vol. 10 (1), pp. 2395244. Date of Electronic Publication: 2024 Sep 10.
DOI:	10.1080/20565623.2024.2395244
Abstrakt:	The emergence of multicancer early detection (MCED) tests holds promise for improving early cancer detection and public health outcomes. However, positive MCED test results require confirmation through recommended cancer diagnostic imaging modalities. To address these challenges, we have developed a consultation and work-up protocol for definitive diagnostic results post MCED testing, named SPOT-MAS. Developed through circulating tumor DNA (ctDNA) analysis and in line with professional guidelines and advisory board consensus, this protocol standardizes information to aid general practitioners in accessing, interpreting and managing SPOT-MAS results. Clinical effectiveness is demonstrated through a series of identified cancer cases. Our research indicates that the protocol could empower healthcare professionals to confidently interpret circulating tumor DNA test results for 5 common types of cancer, thereby facilitating the clinical integration of MCED tests.
Databáze:	MEDLINE
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