Does Antiretroviral Therapy Prevent Human T-Lymphotropic Virus 1 Transmission From a Seropositive Donor to a Kidney Transplant Recipient? A Case Report and Literature Review.

Autor: Monforte A; From the Infectious Diseases Department, and the Infectious Diseases Research Group, Vall d'Hebron Institut de Recerca, Barcelona, Spain., Los-Arcos I, Rando A, Márquez-Algaba E, Moreso FJ, Esperalba J, Falcó V, Pont T, Len O
Jazyk: angličtina
Zdroj: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [Exp Clin Transplant] 2024 Aug; Vol. 22 (8), pp. 641-646.
DOI: 10.6002/ect.2024.0178
Abstrakt: Human T-lymphotropic virus 1 produces a latent infection and disease with poor prognosis. Although its transmission during solid-organ transplant and development of the disease has been described, it is not clear whether antiretroviral treatment could prevent it. We report the first kidney transplant of a donor with human T-lymphotropic virus positivity to a negative recipient who was under antiretroviral treatment without evidence of transmission. We reviewed the literature, which included reports of 55 solid-organ transplant donors with human T-lymphotropic virus positivity to negative recipients, showing high rates of transmission and disease. The benefits of antiretroviral treatment require evaluation in further studies.
Databáze: MEDLINE