Clinical and laboratory characteristics of Toxocara canis infection among children in Ho Chi Minh City, Vietnam.

Autor:	Ha TV; Departme nt of Pediatrics, Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, 2 Duong Quang Trung Str., Dist 10, 72500, Vietnam.; Department of Gastroenterology, Children's Hospital 2, Ho Chi Minh City, 14 Ly Tu Trong Str., Dist 1, 71000, Vietnam., Tang HK; Depar tment of Epidemiology, Faculty of Public Health, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, 2 Duong Quang Trung Str., Dist 10, 71500, Vietnam., Ngo BV; Departme nt of Pediatrics, Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, 2 Duong Quang Trung Str., Dist 10, 72500, Vietnam., Le TPT; Departme nt of Pediatrics, Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, 2 Duong Quang Trung Str., Dist 10, 72500, Vietnam., Le DH; Depar tment of Epidemiology, Faculty of Public Health, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, 2 Duong Quang Trung Str., Dist 10, 71500, Vietnam., Tran YML; Pham Ngoc Thach University of Medicine, Ho Chi Minh City, 2 Duong Quang Trung Str., Dist 10, 72500, Vietnam., Dang DKH; Pham Ngoc Thach University of Medicine, Ho Chi Minh City, 2 Duong Quang Trung Str., Dist 10, 72500, Vietnam., Vo TTN; Department of Family Medicine, Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, 2 Duong Quang Trung Str., Dist 10, 72500, Vietnam.
Jazyk:	angličtina
Zdroj:	Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2024 Sep 10. Date of Electronic Publication: 2024 Sep 10.
DOI:	10.1093/trstmh/trae057
Abstrakt:	Background: This study determines the clinical and paraclinical characteristics of children with Toxocara canis infection and serum eosinophil cut-off values for predicting toxocariasis in the group displaying symptoms of itching, urticaria and erythema. Methods: A cross-sectional study was conducted during March and April 2023 with a sample size of 986 children aged 3-15 y. Results: In total, 140 (14.2%) of the 986 participants had anti-T canis antibodies. The most frequently experienced symptoms in this group were itching (10.1%), abdominal pain (8.2%) and urticaria (3.3%). The rate of IgE increased (37%), and the rates of mild and high eosinophilia were 38% and 2.2%, respectively. There were significant differences in IgE concentration and eosinophil count, and for both IgE concentration and eosinophil count between the two groups with and without toxocariasis. The optimal threshold for eosinophil to predict toxocariasis was 0.38 K/µL, with itching, urticaria and erythema resulting in a sensitivity of 61.5%, a specificity of 82.1% and a receiver operating characteristic curve (area under the curve) of 0.71. Conclusions: This study confirmed a positive association between IgE concentration, eosinophil count and positive serology for T. canis. A general blood count, including eosinophils, is a simple test that can be performed in hospitals. Clinicians should target and screen for T.oxocara canis infection when children display clinical symptoms of itching, urticaria, erythema and eosinophilia. Clinical Trial Registration Number: NCT05208333. (© The Author(s) 2024. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
Databáze:	MEDLINE
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