Deciphering NF-kappaB pathways in smoking-related lung carcinogenesis.

Autor:	Thapa R; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India., Moglad E; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia., Goyal A; Institute of Pharmaceutical Research, GLA University, Mathura, U.P., India., Bhat AA; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India., Almalki WH; Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Kazmi I; Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Alzarea SI; Department of Pharmacology, College of Pharmacy, Jouf University, 72341, Sakaka, Al-Jouf, Saudi Arabia., Ali H; Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India.; Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan., Oliver BG; Woolcock Institute of Medical Research, Macquarie University, Sydney, NSW 2137 Australia.; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007 Australia., MacLoughlin R; Research and Development, Aerogen Limited, IDA Business Park, Galway, Connacht, H91 HE94 Ireland.; School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Leinster, D02 YN77 Ireland.; School of Pharmacy & Pharmaceutical Sciences, Trinity College, Dublin, Leinster, D02 PN40 Ireland., Dureja H; Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, Haryana, India., Singh SK; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.; School of Medical and Life Sciences, Sunway University, Sunway City, 47500, Malaysia., Dua K; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia., Gupta G; Center for Research Impact & Outcome-Chitkara College of Pharmacy, Chitkara University, Punjab.; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.
Jazyk:	angličtina
Zdroj:	EXCLI journal [EXCLI J] 2024 Aug 19; Vol. 23, pp. 991-1017. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024).
DOI:	10.17179/excli2024-7475
Abstrakt:	One of the main causes of death worldwide is lung cancer, which is largely caused by cigarette smoking. The crucial transcription factor NF-κB, which controls inflammatory responses and various cellular processes, is a constitutively present cytoplasmic protein strictly regulated by inhibitors like IκB proteins. Upon activation by external stimuli, it undergoes phosphorylation, translocates into the nucleus, and modulates the expression of specific genes. The incontrovertible association between pulmonary malignancy and tobacco consumption underscores and highlights a public health concern. Polycyclic aromatic hydrocarbons and nitrosamines, potent carcinogenic compounds present in the aerosol emitted from combusted tobacco, elicit profound deleterious effects upon inhalation, resulting in severe perturbation of pulmonary tissue integrity. The pathogenesis of smoking-induced lung cancer encompasses an intricate process wherein NF-κB activation plays a pivotal role, triggered by exposure to cigarette smoke through diverse signaling pathways, including those associated with oxidative stress and pro-inflammatory cytokines. Unraveling the participation of NF-κB in smoking-induced lung cancer provides pivotal insights into molecular processes, wherein intricate crosstalk between NF-κB and pathways such as MAPK and PI3K-Akt amplifies the inflammatory response, fostering an environment conducive to the formation of lung cancer. This study reviews the critical function of NF-κB in the complex molecular pathways linked to the initiation and advancement of lung carcinogenesis as well as potential treatment targets. See also the graphical abstract(Fig. 1). Competing Interests: No authors have any conflict of interest or competing interests to declare. (Copyright © 2024 Thapa et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu