Deep Brain Stimulation restores information processing in parkinsonian cortical networks.

Autor:	Piette C; Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, PSL University, 75005 Paris, France.; Department of Mathematics and Volen National Center for Complex Systems, Brandeis University, MA Waltham, USA., Tin SNW; Service de Physiologie, Explorations Fonctionnelles et Médecine du Sport, Assistance Publique-Hôpitaux de Paris (AP-HP), Avicenne University Hospital, Sorbonne Paris Nord University, 93009 Bobigny, France.; Inserm UMR 1272, Sorbonne Paris Nord University, 93009 Bobigny, France., Liège A; Department of Neurology, Avicenne University Hospital, Sorbonne Paris Nord University, 93009 Bobigny, France., Bloch-Queyrat C; Department of Clinical Research, Avicenne University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), 93009, Bobigny, France., Degos B; Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, PSL University, 75005 Paris, France.; Department of Neurology, Avicenne University Hospital, Sorbonne Paris Nord University, 93009 Bobigny, France., Venance L; Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, PSL University, 75005 Paris, France., Touboul J; Department of Mathematics and Volen National Center for Complex Systems, Brandeis University, MA Waltham, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Aug 28. Date of Electronic Publication: 2024 Aug 28.
DOI:	10.1101/2024.08.25.24310748
Abstrakt:	Parkinson's disease (PD) is a neurodegenerative disorder associated with alterations of neural activity and information processing primarily in the basal ganglia and cerebral cortex. Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) is the most effective therapy when patients experience levodopa-induced motor complications. A growing body of evidence points towards a cortical effect of STN-DBS, restoring key electrophysiological markers, such as excessive beta band oscillations, commonly observed in PD. However, the mechanisms of STN-DBS remain elusive. Here, we aim to better characterize the cortical substrates underlying STN-DBS-induced improvement in motor symptoms. We recorded electroencephalograms (EEG) from PD patients and found that, although apparent EEG features were not different with or without therapy, EEG signals could more accurately predict limb movements under STN-DBS. To understand the origins of this enhanced information transmission under STN-DBS in the human EEG data, we investigated the information capacity and dynamics of a variety of computational models of cortical networks. The extent of improvement in decoding accuracy of complex naturalistic inputs under STN-DBS depended on the synaptic parameters of the network as well as its excitability and synchronization levels. Additionally, decoding accuracy could be optimized by adjusting STN-DBS parameters. Altogether, this work draws a comprehensive link between known alterations in cortical activity and the degradation of information processing capacity, as well as its restoration under DBS. These results also offer new perspectives for optimizing STN-DBS parameters based on clinically accessible measures of cortical information processing capacity. Competing Interests: Competing interests: “All other authors declare they have no competing interests.”
Databáze:	MEDLINE
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