An updated molecular diagnostic for surveillance of tetM in Neisseria gonorrhoeae .

Autor: Palace SG; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Reyes JA; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Vickers EN; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Aatresh AV; Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Harvard College, Cambridge, MA, USA., Shen W; European Molecular Biology Laboratory - European Bioinformatics Institute, Hinxton, UK.; Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, China., Iqbal Z; Milner Centre for Evolution, University of Bath, UK., Grad YH; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Jazyk: angličtina
Zdroj: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Aug 28. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1101/2024.08.26.24312240
Abstrakt: Doxycycline post-exposure prophylaxis (doxy-PEP) for sexually transmitted bacterial infections reduces the risk of syphilis and chlamydia, but effectiveness against gonorrhea is variable, likely attributable to varying resistance rates. As doxy-PEP is incorporated into clinical practice, an urgent unanswered question is whether increased doxycycline use will drive tetracycline-class resistance in Neisseria gonorrhoeae . Here, we report an updated RT-PCR molecular diagnostic to detect the tetM gene that confers high-level tetracycline resistance in N. gonorrhoeae .
Databáze: MEDLINE