Accidental bufotoxin intoxication: Arenobufagin identification by liquid chromatography coupled to mass spectrometry.

Autor:	Bonari A; General Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Mattei ML; General Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Cappelli G; Department of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy., Romano F; General Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Cini N; General Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Luceri F; General Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Squillaci D; Department of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy., Dugheri S; Department of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy., Fanelli A; General Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Mucci N; Department of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy.
Jazyk:	angličtina
Zdroj:	Practical laboratory medicine [Pract Lab Med] 2024 Aug 15; Vol. 41, pp. e00424. Date of Electronic Publication: 2024 Aug 15 (Print Publication: 2024).
DOI:	10.1016/j.plabm.2024.e00424
Abstrakt:	Background: Since ancient times, poisoning, even serious poisoning, has been known to occur during nature walks. Intentional or unintentional ingestion of toxins of animal origin is one of the possible causes of poisoning. Bufadienolide poisoning is a critical case. This is because of its high potency and its ability to cross the blood-brain barrier. Due to the rarity of these poisonings in humans in Central Europe, their identification is often difficult. The following is a case report of a poisoning by toad eggs in an Italina child, that presented vertigo, fussiness and sleepiness. A method of toxin identification using the prince of pharmacotoxicology, liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS), and an innovative reasoning were used. This method can be applied to other poisoning cases. Competing Interests: Alessandro Bonari: None. Mauro Leucio Mattei: None. Giovanni Cappelli: None. Francesca Romano: None. Nicoletta Cini: None. Francesca Luceri: None. Donato Squillaci: None. Stefano Dugheri: None. Alessandra Fanelli: None. Nicola Mucci: None. (© 2024 The Authors. Published by Elsevier B.V.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu