Effect of exogenous lipids contamination on blood gas analysis.
| Autor: | Lippi G; Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy., Pighi L; Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy., Salvagno GL; Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy., Tiziani E; Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy., Castellini ME; Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy., Ferraro R; Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy., Henry BM; Clinical Laboratory, Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Advances in laboratory medicine [Adv Lab Med] 2024 May 07; Vol. 5 (3), pp. 301-306. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024). |
| DOI: | 10.1515/almed-2024-0043 |
| Abstrakt: | Objectives: The purpose of this study was to investigate the effects of contamination of venous blood with a lipid-containing solution on parameters measured by a modern blood gas analyzer. Methods: We collected venous blood from 17 healthcare workers (46 ± 11 years; 53 % women) into three blood gas syringes containing 0 , 5 and 10 % lipid-containing solution. Blood gas analysis was performed within 15 min from sample collection on GEM Premier 5000, while triglycerides and serum indices were assays on Roche COBAS C702. Results: Triglycerides concentration increased from 1.0 ± 0.3 mmol/L in the uncontaminated blood gas syringe, to 39.4 ± 7.8 and 65.3 ± 14.4 mmol/L (both p<0.001) in syringes with 5 and 10 % final lipid contamination. The lipemic and hemolysis indices increased accordingly. Statistically significant variation was noted for all analytes except hematocrit and COHb in the syringe with 5 % lipids, while only COHb did not vary in the syringe with 10 % lipids. Significant increases were observed from 5 % lipid contamination for pO Conclusions: Artifactual hyperlipidemia caused by contamination with exogenous lipids can have a clinically significant impact on blood gas analysis. Manufacturers of blood gas analyzers must be persuaded to develop new instruments equipped with serum indices. Competing Interests: Competing interests: The authors state no conflict of interest. (© 2024 the author(s), published by De Gruyter, Berlin/Boston.) |
| Databáze: | MEDLINE |
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