Left ventricular volumes and function in successful and failed His-BundLe Pacing. A comparative prospective study.

Autor: Notaristefano F; Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy., Barengo A; IRCCS San Raffaele Scientific Institute, Milano, Italy., Spighi L; Department of Cardiology, Hospital degli Infermi, Rimini, Italy., Piraccini S; Department of Cardiology, Hospital S. Maria della Misericordia, Urbino, Italy., Freschini M; Cardiology and Cardiovascular Pathophysiology, University of Perugia and Hospital S. Maria della Misericordia, Perugia, Italy., Sforna S; Cardiology and Cardiovascular Pathophysiology, University of Perugia and Hospital S. Maria della Misericordia, Perugia, Italy., Pesce F; Cardiology and Cardiovascular Pathophysiology, University of Perugia and Hospital S. Maria della Misericordia, Perugia, Italy., Giuffrè G; Department of Cardiology, Hospital 'S. Scolastica', Cassino, Italy., Bagnacani A; Department of Cardiology, Azienda USL IRCCS Reggio Emilia, Reggio Emilia, Italy., D'Ammando M; Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy., Zingarini G; Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy., Notaristefano S; Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy., Cavallini C; Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy., Verdecchia P; Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy.; Fondazione Umbra Cuore e Ipertensione-ONLUS, Perugia, Italy., Sclafani R; Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy., Angeli F; Department of Medicine and Surgery, Varese and Department of Medicine and Cardiopulmonary Rehabilitation, Maugeri Care and Research Institute, IRCCS Tradate, University of Insubria, Varese, Italy.
Jazyk: angličtina
Zdroj: Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2024 Nov; Vol. 35 (11), pp. 2153-2160. Date of Electronic Publication: 2024 Sep 09.
DOI: 10.1111/jce.16426
Abstrakt: Introduction: Initial data suggest that His Bundle Pacing (HBP) could preserve long-term cardiac structure and function better than Right Ventricular Pacing (RVP), but evidence is limited.
Methods: We studied consecutive patients with baseline ejection fraction (EF) ≥ 50% who underwent HBP attempt, either successful (HBP group) or failed (RVP group). Two-dimensional (2D) and three-dimensional (3D) echocardiography were carried out at baseline and after 6 months of ventricular pacing burden > 20%.
Results: Among 68 patients, 40 underwent successful HBP, and 28 RVP. The HBP and RVP groups did not differ for age, sex and pacing indication. At baseline, the HBP and RVP groups did not differ for 2D EF (62% vs. 62%), 3D EF (60% vs. 63%), 2D (-19% vs. -19%) and 3D global longitudinal strain (GLS) (-15% vs. -16%). After 6 months, 2D EF (-3.86%) and 3D EF (-5.71%) significantly decreased in the RVP group and did not change in the HBP group (p for interaction .006 and <.001, respectively). 2D GLS (3.08%) and 3D GLS (2.22%) significantly increased in the RVP group, but did not change in the HBP group (p for interaction .013 and <.016, respectively). Pacing induced cardiomyopathy (PICM) (EF drop ≥ 10% and EF < 50%) occurred in 14% (RVP) versus 0% (HBP) of patients (p = .025).
Conclusions: Successful HBP was superior to RVP in preserving LV systolic function despite a high ventricular pacing burden, and was less frequently associated with PICM.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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