Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia.

Autor: Liu T; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Xu K; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Pardeshi A; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Myint SS; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Kang AY; School of Public Health, University of California Berkeley, Berkeley, CA, USA., Morimoto LM; School of Public Health, University of California Berkeley, Berkeley, CA, USA., Lieber MR; Departments of Pathology, Biochemistry, Molecular Microbiology & Immunology, and Section of Molecular & Computational Biology (Department of Biological Sciences), University of Southern California, Los Angeles, CA, USA., Wiemels JL; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Kogan SC; Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Metayer C; School of Public Health, University of California Berkeley, Berkeley, CA, USA., de Smith AJ; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. desmith@usc.edu.; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. desmith@usc.edu.
Jazyk: angličtina
Zdroj: Leukemia [Leukemia] 2024 Nov; Vol. 38 (11), pp. 2492-2496. Date of Electronic Publication: 2024 Sep 09.
DOI: 10.1038/s41375-024-02407-3
Databáze: MEDLINE