Single-point macromolecular proton fraction mapping using a 0.3 T permanent magnet MRI system: phantom and healthy volunteer study.

Autor: Fujiwara Y; Department of Medical Imaging Technology, Faculty of Life Sciences, Kumamoto University, 4-24-1, Kuhonji, Chuo-Ku, Kumamoto, 862-0976, Japan. yfuji@kumamoto-u.ac.jp., Eitoku S; Department of Radiology, Hospital of the University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-Ku, Kitakyushu, 807-8556, Japan., Sakae N; Department of Neurology, National Hospital Organization Omuta National Hospital, 1044-1, Tachibana, Omuta, 837-0911, Japan., Izumi T; Department of Radiology, National Hospital Organization Kumamoto Saishun Medical Center, 2659 Suya, Koshi, Kumamoto, 861-1196, Japan., Kumazoe H; Department of Radiology, National Hospital Organization Omuta National Hospital, 1044-1, Tachibana, Omuta, 837-0911, Japan., Kitajima M; Department of Diagnostic Imaging Technology, Faculty of Life Sciences, Kumamoto University, 4-24-1, Kuhonji, Chuo-Ku, Kumamoto, 862-0976, Japan.
Jazyk: angličtina
Zdroj: Radiological physics and technology [Radiol Phys Technol] 2024 Sep 09. Date of Electronic Publication: 2024 Sep 09.
DOI: 10.1007/s12194-024-00843-5
Abstrakt: In a 0.3 T permanent-magnet magnetic resonance imaging (MRI) system, quantifying myelin content is challenging owing to long imaging times and low signal-to-noise ratio. macromolecular proton fraction (MPF) offers a quantitative assessment of myelin in the nervous system. We aimed to demonstrate the practical feasibility of MPF mapping in the brain using a 0.3 T MRI. Both 0.3 T and 3.0 T MRI systems were used. The MPF-mapping protocol used a standard 3D fast spoiled gradient-echo sequence based on the single-point reference method. Proton density, T 1 , and magnetization transfer-weighted images were obtained from a protein phantom at 0.3 T and 3.0 T to calculate MPF maps. MPF was measured in all phantom sections to assess its relationship to protein concentration. We acquired MPF maps for 16 and 8 healthy individuals at 0.3 T and 3.0 T, respectively, measuring MPF in nine brain tissues. Differences in MPF between 0.3 T and 3.0 T, and between 0.3 T and previously reported MPF at 0.5 T, were investigated. Pearson's correlation coefficient between protein concentration and MPF at 0.3 T and 3.0 T was 0.92 and 0.90, respectively. The 0.3 T MPF of brain tissue strongly correlated with 3.0 T MPF and literature values measured at 0.5 T. The absolute mean differences in MPF between 0.3 T and 0.5 T were 0.42% and 1.70% in white and gray matter, respectively. Single-point MPF mapping using 0.3 T permanent-magnet MRI can effectively assess myelin content in neural tissue.
(© 2024. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.)
Databáze: MEDLINE
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