Novel chitosan-based hydrogels as promising wound dressing materials with advanced properties.

Autor: Lombardo G; Instituto Tecnológico de Buenos Aires (ITBA), Lavardén 315, 1437, Ciudad de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; YPF Tecnología S.A., Av. del Petróleo s/n, Berisso 1923, Buenos Aires, Argentina., Dorm BC; University of Araraquara - UNIARA, Rua Carlos Gomes, 1217, CEP: 14801-340 Araraquara, SP, Brazil., Salvay AG; Universidad Nacional de Quilmes, Departamento de Ciencia y Tecnología, Bernal, Argentina., Franzi L; Instituto Tecnológico de Buenos Aires (ITBA), Lavardén 315, 1437, Ciudad de Buenos Aires, Argentina., Gaffney ML; Instituto Tecnológico de Buenos Aires (ITBA), Lavardén 315, 1437, Ciudad de Buenos Aires, Argentina., Peredo Camio JB; Instituto Tecnológico de Buenos Aires (ITBA), Lavardén 315, 1437, Ciudad de Buenos Aires, Argentina., Trovatti E; University of Araraquara - UNIARA, Rua Carlos Gomes, 1217, CEP: 14801-340 Araraquara, SP, Brazil., Rossi E; Instituto Tecnológico de Buenos Aires (ITBA), Lavardén 315, 1437, Ciudad de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina., Errea MI; Instituto Tecnológico de Buenos Aires (ITBA), Lavardén 315, 1437, Ciudad de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address: merrea@itba.edu.ar.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Nov; Vol. 279 (Pt 4), pp. 135423. Date of Electronic Publication: 2024 Sep 07.
DOI: 10.1016/j.ijbiomac.2024.135423
Abstrakt: Herein, four different grafted chitosans were synthesized by covalent attachment of glycine, L-arginine, L-glutamic acid, or L-cysteine to the chitosan chains. All products were subsequently permethylated to obtain their corresponding quaternary ammonium salts to enhance the inherent antimicrobial properties of native chitosan. In all cases, transparent hydrogels with the following remarkable characteristics were obtained: i) high-water absorption capacity (32-44 g H 2 O per g of polymer), ii) viscoelastic behavior at low deformations, iii) flexibility when subjected to deformations and iv) stability over long time scales. All the permethylated derivatives successfully inhibited 100 % of the growth of S. aureus. They also exhibited higher antimicrobial activity against E. coli than native chitosan. The structure of the chemically crosslinked products was more stable under external perturbations than that of the physically crosslinked ones. Between the chemically crosslinked products, the permethylated glutamic acid-grafted chitosan exhibited a noteworthy higher water absorption capacity with respect to that modified with cysteine, which makes it the most promising material for various industrial applications, including biomedical and food industries. Regarding biomedical applications, this derivative met the required physicochemical criteria for wound dressings, which encourages the pursuit of biological studies necessary to ensure the safety of its use for this application.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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