Exploring the interplay between cannabinoids and thymic functions.

Autor:	Lins MP; Laboratory of Immunology, Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá-MT, 78060-900, Brazil.; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, 21040-360, Brazil., de Melo IS; Laboratory of Neuropharmacology and Integrative Physiology, Institute of Biological and Health Sciences, Federal University of Alagoas, Maceió, 57072-900, Brazil.
Jazyk:	angličtina
Zdroj:	Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2024 Nov 01; Vol. 202 (1), pp. 1-12.
DOI:	10.1093/toxsci/kfae114
Abstrakt:	Cannabinoids, derived from the Cannabis sativa plant, have garnered increasing attention for their potential therapeutic applications in various diseases. The pharmacologically active compounds in Cannabis, such as delta-9-tetrahydrocannabinol and cannabidiol, exhibit diverse immunomodulatory properties. Although studies have explored the effects of cannabinoids on immune function, their specific interactions with the thymus, a primary immune organ critical for T-cell development and maturation, remain an intriguing area of investigation. As the thymus plays a fundamental role in shaping the immune repertoire, understanding the interplay between cannabinoids and thymic function may shed light on potential benefits or concerns associated with Cannabis-based therapies. This article aims to provide an overview of the current scientific knowledge regarding the impact of medicinal Cannabis on the thymus and its implications for disease treatment and immune health. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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