| Autor: |
Chen X; College of Chemical Engineering, Huaqiao University, Xiamen 361021, China., Li X; College of Chemical Engineering, Huaqiao University, Xiamen 361021, China., Xiao X; College of Chemical Engineering, Huaqiao University, Xiamen 361021, China., Long R; College of Chemical Engineering, Huaqiao University, Xiamen 361021, China., Chen B; College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.; Fujian Provincial Key Laboratory of Biochemical Technology & Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China.; State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200438, China., Lin Y; College of Chemical Engineering, Huaqiao University, Xiamen 361021, China., Wang S; Fujian Provincial Key Laboratory of Biochemical Technology & Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China.; College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China., Liu Y; College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.; Fujian Provincial Key Laboratory of Biochemical Technology & Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China. |
| Abstrakt: |
Diabetic foot ulcer (DFU) is a common and severe complication of diabetes characterized by wound neuropathy, ischemia, and susceptibility to infection, making its treatment difficult. Dressings are commonly used in treating diabetic wounds; however, they have disadvantages, including lack of flexibility and mechanical strength, lack of coagulation activity, resistance to biodegradation, and low drug delivery efficiency. Developing more effective strategies for diabetic wound treatment has become a new focus. Microneedles (MN) can be used as a drug delivery platform for DFU wounds, allowing safe, effective, painless and minimally invasive medication administration through the skin. Herein, PDA@Ag/SerMA microneedles were prepared by combining the photothermal properties of polydopamine (PDA), the antimicrobial properties of argentum (Ag), and the ability of sericin methacryloyl (SerMA) to promote cell mitosis to accelerate wound healing and treat diabetic ulcer wounds. The results revealed that PDA@Ag/SerMA microneedles exhibited approximately 100% antimicrobial efficacy against Staphylococcus aureus and Escherichia coli under 808 nm near-infrared (NIR) irradiation. Furthermore, the wound healing rate of mice reached 95% within 12 days, which demonstrated the excellent antibacterial properties and wound healing efficacy of PDA@Ag/SerMA microneedles at cellular and animal levels, providing a potential solution for treating DFU. |
