Fetal Cystic Lymphatic Malformations: Systematic Review on Pregnancy and Neonatal Outcomes.

Autor: Nzelu D; Women's Health, University College London Hospitals NHS Foundation Trust, London, UK., Panayotidis I; Women's Health, Barking, Havering and Redbridge University Hospitals NHS Trust, London, UK., Smith GD; Plastic Surgery, Great Ormond Street Hospital for Children NHS Trust, London, UK., Pandya P; Women's Health, University College London Hospitals NHS Foundation Trust, London, UK.
Jazyk: angličtina
Zdroj: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine [J Ultrasound Med] 2024 Dec; Vol. 43 (12), pp. 2327-2337. Date of Electronic Publication: 2024 Sep 09.
DOI: 10.1002/jum.16566
Abstrakt: Objective: Evaluate pregnancy and neonatal outcomes with fetal cystic lymphatic malformations (LMs), excluding those arising from the posterior neck, to facilitate patient counseling.
Method: A systematic review was performed in accordance with PRISMA guidance. Case series and case reports published between 2000 and 2022 were included.
Results: Sixty-five studies (96 fetuses) met the inclusion criteria. The average gestational age at diagnosis was 25.5 weeks with the commonest location being the anterior neck (28%). All patients were diagnosed with LM using two-dimensional (2D) ultrasound. Prenatal progression in LM size, presence of intralesional bleeding, or fetal hydrops occurred in 70% (41/59), 9% (5/59), and 3% (2/59), respectively. Chromosomal and structural abnormalities were reported in 4% (2/52) and 2% (2/96), respectively. Overall livebirth rate was 94% (79/84); 12/96 resulted in termination and 5/84 in in utero demise. The average gestational age of delivery was 37.7 weeks. Exactly 19% (15/79) had a vaginal birth, of which shoulder dystocia occurred in one infant. Ex utero intrapartum treatment (EXIT) procedure was performed in 13% (10/79). Postnatal treatment commonly involved surgical excision 38% (30/79), sclerotherapy in 21.5% (17/79), or combination of both in 11.4% (9/79). Of those with reported follow-up, 4 died within 1 year, 1 developed heart failure at 2 years of life, and the remaining 44 had normal developmental outcomes.
Conclusion: Fetal cystic LMs, excluding those in the posterior neck, are not commonly associated with chromosomal, or additional structural abnormalities. They usually increase in size before delivery with only a minority developing complications. The good developmental outcome was reported in all survivors.
(© 2024 American Institute of Ultrasound in Medicine.)
Databáze: MEDLINE
Externí odkaz: