Optic Disc Infiltration as a Sign of Multiple Myeloma Recurrence.

Autor:	Pantelidou M; 2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Dimitriou E; 2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Gkontopoulos K; 2nd Department of Propaedeutic Internal Medicine, Hematology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Thomopoulos T; 2nd Department of Propaedeutic Internal Medicine, Hematology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Pappa V; 2nd Department of Propaedeutic Internal Medicine, Hematology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Papageorgiou SG; 2nd Department of Propaedeutic Internal Medicine, Hematology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Theodossiadis P; 2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Chatziralli I; 2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Journal of hematology [J Hematol] 2024 Aug; Vol. 13 (4), pp. 164-167. Date of Electronic Publication: 2024 Aug 15.
DOI:	10.14740/jh1267
Abstrakt:	Multiple myeloma is a plasma cell dyscrasia with an age-standardized incidence of 3 - 4 per 100,000 in the Caucasian population. It is the second most common hematological malignancy after non-Hodgkin lymphoma, representing 1% of all cancers. Herein, we present a case report of multiple myeloma with ocular involvement as a sign of recurrence. A 62-year-old woman, with a known history of lambda light chain multiple myeloma, presented with reduced visual acuity in both eyes while on maintenance chemotherapy. The patient also had mild unsteadiness and fatigue. Fundus examination revealed bilateral optic disc swelling and hemorrhages of the posterior pole. Magnetic resonance imaging disclosed no abnormalities. Although no biopsy of the optic nerve was possible, intracranial pressure was elevated and cerebrospinal fluid was riddled with neoplastic cells, affirming the diagnosis. After 2 months of chemotherapy, visual function and the appearance of the posterior pole returned to normal. In cases of multiple myeloma, mechanisms, such as hyperviscosity syndrome, microvascular impairment and optic nerve and meningeal infiltration on a cellular level may have played a pivotal role in the ocular involvement, which can be the first sign of recurrence. Competing Interests: The authors declare that they do not have any conflict of interest. (Copyright 2024, Pantelidou et al.)
Databáze:	MEDLINE
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