Lactate Monitoring in Intensive Care: A Comprehensive Review of Its Utility and Interpretation.

Autor:	Deulkar P; Critical Care Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute Of Higher Education and Research, Wardha, IND., Singam A; Critical Care Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute Of Higher Education and Research, Wardha, IND., Mudiganti VNKS; Critical Care Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute Of Higher Education and Research, Wardha, IND., Jain A; Critical Care Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute Of Higher Education and Research, Wardha, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 07; Vol. 16 (8), pp. e66356. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024).
DOI:	10.7759/cureus.66356
Abstrakt:	Lactate monitoring is critical in managing critically ill patients in intensive care settings. Elevated lactate levels often signify underlying metabolic disturbances such as tissue hypoxia, anaerobic metabolism, or impaired lactate clearance, which are prevalent in conditions like sepsis, shock, and trauma. Understanding the physiological basis of lactate production and its significance in clinical practice is essential for interpreting its diagnostic and prognostic value. This comprehensive review aims to explore the utility of lactate monitoring across various critical care scenarios. It provides an overview of lactate's metabolic pathways, methods of measurement, and the clinical implications of interpreting lactate levels in different contexts. Additionally, the review discusses current evidence on lactate-guided therapeutic interventions and highlights challenges and limitations to their application. By synthesizing the existing literature and clinical insights, this review aims to enhance the understanding of the role of lactate monitoring in assessing disease severity, guiding treatment strategies, and predicting outcomes in critically ill patients. Ultimately, this review underscores the importance of integrating lactate monitoring into routine clinical practice to optimize patient care and improve clinical outcomes in intensive care settings. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Deulkar et al.)
Databáze:	MEDLINE
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