Gastric cancer and brain metastasis: A systematic review and meta‑analysis.

Autor: Fotakopoulos G; Department of Neurosurgery, General University Hospital of Larisa, 41221 Larisa, Greece., Christodoulidis G; Department of General Surgery, General University Hospital of Larisa, 41221 Larisa, Greece., Georgakopoulou VE; Department of Pathophysiology, National and Kapodistrian University of Athens, 11527 Athens, Greece., Trakas N; Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece., Skapani P; Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece., Panagiotopoulos K; Biochemistry Laboratory, General Hospital of Athens 'Georgios Gennimatas', 11527 Athens, Greece., Spandidos DA; Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece., Foroglou N; First Department of Neurosurgery, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Jazyk: angličtina
Zdroj: Molecular and clinical oncology [Mol Clin Oncol] 2024 Aug 19; Vol. 21 (5), pp. 77. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024).
DOI: 10.3892/mco.2024.2775
Abstrakt: Gastric cancer (GC) constitutes one of the most wide-ranging cancers, with brain metastasis (BM) being a markedly uncommon and unfavorable outcome. The present meta-analysis evaluated the relationship between no-surgical treatment vs. additional surgical BM resection on the patient's quality of life and potential survival using electronic databases, including PubMed (1980-April 2024), Medline (1980-April 2024), Cochrane Library, and EMBASE (1980-April 2024). After a literature search, six articles were included in the final study pool. The number of patients with BM and conservative treatment was 289 (80.05%) compared with those that underwent an additional surgical resection 72 (19.95%). The mean age was 59.2 years, and the males were 195 (73.8%) of 264 available from five studies. The findings of the present meta-analysis revealed that the curative effect of BM tumor resection on patients with GC undergoing additional treatment with stereotactic radiosurgery, whole-brain radiotherapy or chemotherapy was favorable for their survival.
Competing Interests: DAS is the Editor-in-Chief for the journal, but had no personal involvement in the reviewing process, or any influence in terms of adjudicating on the final decision, for this article. The other authors declare that they have no competing interests.
(Copyright: © 2024 Fotakopoulos et al.)
Databáze: MEDLINE
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