Low-Dose Radiotherapy Attenuates Experimental Autoimmune Arthritis by Inducing Apoptosis of Lymphocytes and Fibroblast-Like Synoviocytes.

Autor:	Kim BG; Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea., Choi HS; Department of Radiation Oncology, Gyeongsang National University Changwon Hospital, Changwon 51472, Korea.; Department of Radiation Oncology and Institute of Health Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea., Choe YH; Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Veterinary Obstetrics, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea.; Lillehei Heart Institute and Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN 55414, USA., Jeon HM; Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju 52727, Korea., Heo JY; Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju 52727, Korea., Cheon YH; Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.; Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju 52727, Korea., Kang KM; Department of Radiation Oncology, Gyeongsang National University Changwon Hospital, Changwon 51472, Korea.; Department of Radiation Oncology and Institute of Health Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea., Lee SI; Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.; Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju 52727, Korea., Jeong BK; Department of Radiation Oncology and Institute of Health Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.; Department of Radiation Oncology, Gyeongsang National University Hospital, Jinju 52727, Korea., Kim M; Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju 52727, Korea.; Department of Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.; Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.
Jazyk:	angličtina
Zdroj:	Immune network [Immune Netw] 2024 Aug 12; Vol. 24 (4), pp. e32. Date of Electronic Publication: 2024 Aug 12 (Print Publication: 2024).
DOI:	10.4110/in.2024.24.e32
Abstrakt:	Low-dose radiotherapy (LDRT) has been explored as a treatment option for various inflammatory diseases; however, its application in the context of rheumatoid arthritis (RA) is lacking. This study aimed to elucidate the mechanism underlying LDRT-based treatment for RA and standardize it. LDRT reduced the total numbers of immune cells, but increased the apoptotic CD4 + T and B220 + B cells, in the draining lymph nodes of collagen induced arthritis and K/BxN models. In addition, it significantly reduced the severity of various pathological manifestations, including bone destruction, cartilage erosion, and swelling of hind limb ankle. Post-LDRT, the proportion of apoptotic CD4 + T and CD19 + B cells increased significantly in the PBMCs derived from human patients with RA. LDRT showed a similar effect in fibroblast-like synoviocytes as well. In conclusion, we report that LDRT induces apoptosis in immune cells and fibro-blast-like synoviocytes, contributing to attenuation of arthritis. Competing Interests: Conflict of Interest: The authors declare no potential conflicts of interest. (Copyright © 2024. The Korean Association of Immunologists.)
Databáze:	MEDLINE
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