Pestiorosins A-F, New Papulacandins Isolated from the Fungus Pestalotiopsis rosea YNJ21.

Autor: Lu Y; School of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130117, China.; Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Duan MH; School of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130117, China., Zhao X; Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Zhang Y; Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Yang Y; Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Xu R; Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Kang YS; Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Wang ZL; Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Zhang YZ; Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China., Li CW; Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Sep 09, pp. e202401921. Date of Electronic Publication: 2024 Sep 09.
DOI: 10.1002/cbdv.202401921
Abstrakt: Six previously unreported papulacandins, namely pestiorosins A-F (1-6), were isolated from the fermentation products of the fungus Pestalotiopsis rosea YNJ21 isolated from the fruitbody of Amanita exitialis. The structures of these compounds, along with a known compound called pestiocandin (7), were determined using MS, NMR data, and modified Mosher's method. All compounds exhibited significant antifungal activity against Candida albicans, with MIC values ranging from 0.06 to 2.00 μg/mL. In terms of cytotoxicity assays, compounds 3 and 6 demonstrated moderate inhibitory activity against human breast cancer MCF-7 cells with IC50 values of 24.50 and 16.83 μM, respectively. On the other hand, compound 7 displayed similar levels of inhibitory activity against mice microglial BV2 cells with an IC50 value of 24.51 μM.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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