Lauric acid with or without levodopa ameliorates Parkinsonism in genetically modified model of Drosophila melanogaster via the oxidative-inflammatory-apoptotic pathway.

Autor: Idowu OK; Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria.; Department of Anatomy, College of Health Sciences, Osun State University, Osogbo, Nigeria., Dosumu OO; Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria., Boboye AS; Department of Anatomy, College of Health Sciences, Federal University of Technology, Akure, Nigeria., Oremosu AA; Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria., Mohammed AA; Department of Human Anatomy, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Butare, Rwanda.
Jazyk: angličtina
Zdroj: Brain and behavior [Brain Behav] 2024 Sep; Vol. 14 (9), pp. e70001.
DOI: 10.1002/brb3.70001
Abstrakt: Background: Parkinson's disease (PD), the most prevalent type of Parkinsonism, is a progressive neurological condition characterized by a range of motor and non-motor symptoms. The complicated etiology of PD is thought to involve a summation of aging, genetic predisposition, and environmental variables. However, the α-synuclein protein plays a significant role in the disease's pathophysiology.
Materials and Methods: The UAS-α-Syn and Ddc-Gal4 strains were crossed to produce offspring referred to as PD flies. The entire population of flies was divided into five groups, each having about 100 flies and five replicates. The control group (w 1118 ) and the PD group not receiving treatment were exposed to lauric acid (LA)/levodopa (LD)-free diet, while the PD groups that received treatments were fed with either a 250 mg/kg LA diet, a 250 mg/kg LD diet, or a combination of the two for 21 days. Longevity, geotaxis, and olfactory assays were performed in addition to other biochemical tests.
Results: As a result of the overexpression of α-synuclein, the locomotive capacity, lifespan, and antioxidant status were all significantly (p < .05) reduced, and the apoptotic and neuroinflammatory activities were increased. Nevertheless, the majority of the treated flies improved significantly (p < .05).
Conclusion: LA, whether combined with LD or not, elicited a significant response in α-synuclein/dopa decarboxylase genetically modified Drosophila melanogaster Parkinsonism models.
(© 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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