A Comprehensive Consolidation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Bronchopulmonary Dysplasia.

Autor:	Bahrami R; Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Golshan-Tafti M; Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran., Dastgheib SA; Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Alijanpour K; General Practitioner, Babol University of Medical Sciences, Babol, Iran., Yeganegi M; Department of Obstetrics and Gynecology, Iranshahr University of Medical Sciences, Iranshahr, Iran., Lookzadeh MH; Mother and Newborn Health Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Mirjalili SR; Mother and Newborn Health Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Azizi S; Shahid Akbarabadi Cilinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran., Aghasipour M; Department of Cancer Biology, College of Medicine, University of Cincinnati, OH, USA., Shiri A; Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Noorishadkam M; Mother and Newborn Health Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Neamatzadeh H; Mother and Newborn Health Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Jazyk:	angličtina
Zdroj:	Fetal and pediatric pathology [Fetal Pediatr Pathol] 2024 Nov-Dec; Vol. 43 (6), pp. 436-454. Date of Electronic Publication: 2024 Sep 08.
DOI:	10.1080/15513815.2024.2400145
Abstrakt:	Background: This meta-analysis aims to evaluate the potential link between common variations in the Surfactant Protein-B (SFTPB) gene and the risk of bronchopulmonary dysplasia (BPD) in preterm neonates. Methods: All pertinent articles published prior to February 1, 2024, in PubMed, Web of Science, EMBASE, CNKI, and Scopus databases were reviewed. Results: Nineteen case-control studies involving 1149 BPD cases and 1845 non-BPD controls, were analyzed. Combined data indicated a significant link between SFTPB -18 A > C and Intron 4 VNTR polymorphisms with increased BPD susceptibility, while the 1580 C > T polymorphism provides a protective impact on BPD initiation. Conclusions: Pooled data indicated a significant association between SFTPB -18 A > C and Intron 4 VNTR polymorphisms with increased BPD risk, whereas the 1580 C > T polymorphism confers protection. These findings suggest a genetic susceptibility to BPD, underscoring the complex interplay of different genetic elements in its development.
Databáze:	MEDLINE
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