Thermosensitive injectable fibrillar gels based on cellulose nanocrystals grafted with poly(N-isopropylacrylamide) as biocompatible brain implants.

Autor: Belyaeva AA; Center of Soft Matter and Physics of Fluids, N.E. Bauman Moscow State Technical University, 2nd Baumanskaya Str,.5/1, Moscow 105005, Russia; Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severniy pr., Chernogolovka, Moscow region 142432, Russia., Averchuk AS; Center of Soft Matter and Physics of Fluids, N.E. Bauman Moscow State Technical University, 2nd Baumanskaya Str,.5/1, Moscow 105005, Russia; Research Center of Neurology, Volokolamskoe highway, 80, Moscow 125367, Russia., Rozanova NA; Center of Soft Matter and Physics of Fluids, N.E. Bauman Moscow State Technical University, 2nd Baumanskaya Str,.5/1, Moscow 105005, Russia; Research Center of Neurology, Volokolamskoe highway, 80, Moscow 125367, Russia., Alexandrova OP; Center of Soft Matter and Physics of Fluids, N.E. Bauman Moscow State Technical University, 2nd Baumanskaya Str,.5/1, Moscow 105005, Russia; Research Center of Neurology, Volokolamskoe highway, 80, Moscow 125367, Russia., Solomakha OA; Institute of Macromolecular Compounds of Russian Academy of Sciences, Bolshoy Prospekt, 31, St. Petersburg 199004, Russia., Nashchekina YA; Institute of Cytology, Russian Academy of Sciences, Tikhoretskiy pr. 4, St. Petersburg 194064, Russia., Korzhikov-Vlakh VA; Center of Soft Matter and Physics of Fluids, N.E. Bauman Moscow State Technical University, 2nd Baumanskaya Str,.5/1, Moscow 105005, Russia; Institute of Chemistry, Saint-Petersburg State University, Universitetskiy pr. 26, St. Petersburg 198504, Russia., Yurchenko SO; Center of Soft Matter and Physics of Fluids, N.E. Bauman Moscow State Technical University, 2nd Baumanskaya Str,.5/1, Moscow 105005, Russia., Salmina AB; Center of Soft Matter and Physics of Fluids, N.E. Bauman Moscow State Technical University, 2nd Baumanskaya Str,.5/1, Moscow 105005, Russia; Research Center of Neurology, Volokolamskoe highway, 80, Moscow 125367, Russia., Korzhikova-Vlakh EG; Institute of Macromolecular Compounds of Russian Academy of Sciences, Bolshoy Prospekt, 31, St. Petersburg 199004, Russia. Electronic address: vlakh@mail.ru., Morozova SM; Center of Soft Matter and Physics of Fluids, N.E. Bauman Moscow State Technical University, 2nd Baumanskaya Str,.5/1, Moscow 105005, Russia; Moscow Institute of Physics and Technology, National Research University, Institutskiy per. 9, 141700 Dolgoprudny, Russia. Electronic address: sofiionova@yandex.ru.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2024 Dec 15; Vol. 346, pp. 122596. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1016/j.carbpol.2024.122596
Abstrakt: Drug treatment of glioblastoma, the most aggressive and widespread form of brain cancer, is complicated due to the difficulty of penetration of chemotherapeutic drugs through the blood-brain barrier (BBB). Moreover, with surgical removal of tumors, in 90 % of cases they reappear near the original focus. To solve this problem, we propose to use hydrogel based on cellulose nanocrystals grafted with poly(N-isopropylacrylamide) (CNC-g-PNIPAM) as a promising material for filling postoperative cavities in the brain with the release of antitumor drugs. The CNC-g-PNIPAM is formed by "grafting to" method for precise control of molecular weight and grafting density. This colloidal system is liquid under injection conditions (at r. t.) and turns into a gel at human body temperature (when filling the postoperative area). It was shown for the first time that due to the rod-shaped of CNC, the gel has a fibrillar structure and, thus, mechanical properties similar to those of brain tissue, including nonlinear mechanics (strain-stiffening and compression softening). The biocompatibility of the hydrogel with primary brain cells is demonstrated. In addition, the release of the antitumor drug paclitaxel from the hydrogel and its antitumor activity is shown. The resulting nanocolloid system provides an innovative alternative approach to filling postoperative cavities and can be used for postoperative treatment due to the programmable release of drugs, as well as for in vitro modeling of tumor interaction with the BBB affecting drug transport in the brain.
Competing Interests: Declaration of competing interest Sofia Morozova reports financial support was provided by Russian Science Foundation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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