Past, present, and future biomarkers of kidney function and injury: The relationship with antibiotics.

Autor: Chang J; Department of Pharmacy Practice (J.C., G.M.P., R.J., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Pharmacometrics Center of Excellence (J.C., G.M.P., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Department of Pharmacy (J.C., M.H.S.), Northwestern Memorial Hospital, Chicago, Illinois, USA., Pais GM; Department of Pharmacy Practice (J.C., G.M.P., R.J., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Pharmacometrics Center of Excellence (J.C., G.M.P., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA., Barreto EF; Department of Pharmacy (E.F.B.), Mayo Clinic, Rochester, Minnesota, USA., Young B; Chicago College of Osteopathic Medicine (B.Y., H.S., Z.S., C.C.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA., Scott H; Chicago College of Osteopathic Medicine (B.Y., H.S., Z.S., C.C.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA., Schwartz Z; Chicago College of Osteopathic Medicine (B.Y., H.S., Z.S., C.C.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA., Cartwright C; Chicago College of Osteopathic Medicine (B.Y., H.S., Z.S., C.C.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA., Jubrail R; Department of Pharmacy Practice (J.C., G.M.P., R.J., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA., Srivastava A; Division of Nephrology (A.S.), University of Illinois-Chicago, Chicago, Illinois, USA., Scheetz MH; Department of Pharmacy Practice (J.C., G.M.P., R.J., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Pharmacometrics Center of Excellence (J.C., G.M.P., M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA; Department of Pharmacy (J.C., M.H.S.), Northwestern Memorial Hospital, Chicago, Illinois, USA; Department of Pharmacology (M.H.S.), Midwestern University-Downers Grove Campus, Downers Grove, Illinois, USA. Electronic address: mschee@midwestern.edu.
Jazyk: angličtina
Zdroj: International journal of antimicrobial agents [Int J Antimicrob Agents] 2024 Nov; Vol. 64 (5), pp. 107332. Date of Electronic Publication: 2024 Sep 07.
DOI: 10.1016/j.ijantimicag.2024.107332
Abstrakt: Routinely used kidney biomarkers of injury and function such as serum creatinine and urine albumin to creatinine ratio, are neither sensitive nor specific. Future biomarkers are being developed for clinical use and have already been included in guidance from groups such as the U.S. Food and Drug Administration and the Predictive Safety Testing Consortium. These biomarkers have important implications for early identification of kidney injury and more accurate measurement of kidney function. Many antibiotics are either eliminated by the kidney or can cause clinically significant nephrotoxicity. As a result, clinicians should be familiar with new biomarkers of kidney function and injury, their place in clinical practice, and applications for antibiotic dosing.
(Copyright © 2024 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.)
Databáze: MEDLINE
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