Advantages of online supercritical fluid extraction and chromatography hyphenated to mass spectrometry to analyse plastic additives in laboratory gloves.

Autor: Caux B; ICOA, CNRS UMR 7311, University of Orleans, Pôle de chimie, rue de Chartres - BP 6759 45067, Orléans Cedex 2, France; Shimadzu France, Le luzard 2, Bat A, Bd Salvador Allende Noisiel, Marne-la-Vallée 77448, France., De Saint Jores C; ICOA, CNRS UMR 7311, University of Orleans, Pôle de chimie, rue de Chartres - BP 6759 45067, Orléans Cedex 2, France., Abou-Naccoul R; Shimadzu France, Le luzard 2, Bat A, Bd Salvador Allende Noisiel, Marne-la-Vallée 77448, France., Horie S; Shimadzu Europa Gmbh, Albert-Hahn-Straße 6-10, Duisburg, 47269, Germany., West C; ICOA, CNRS UMR 7311, University of Orleans, Pôle de chimie, rue de Chartres - BP 6759 45067, Orléans Cedex 2, France. Electronic address: caroline.west@univ-orleans.fr.
Jazyk: angličtina
Zdroj: Journal of chromatography. A [J Chromatogr A] 2024 Oct 25; Vol. 1735, pp. 465323. Date of Electronic Publication: 2024 Aug 30.
DOI: 10.1016/j.chroma.2024.465323
Abstrakt: Plastic additives are introduced in plastic material formulations, along with organic polymers, to offer different properties such as stability, plasticity or color. However, plastic additives may migrate from the plastic material to the content (in case of plastic containers) or to the material in contact with the plastic, like human skin. In the case of plastic medical devices, this migration is of particular interest, as plastic additives may be deleterious to health. In the present paper, we examined the interest of combining supercritical fluid extraction (SFE) to supercritical fluid chromatography (SFC) hyphenated to mass spectrometry (MS) in an online system to characterize plastic additives in laboratory gloves, taken as samples of medical devices. A set of target compounds comprising 18 plasticizers, 4 antioxidants and 2 lubricants was defined and their detectability with MS was examined, where it appeared that electrospray ionization (ESI) provided better detectability than atmospheric pressure chemical ionization (APCI). After examining possible stationary phases with the help of Derringer desirability function, an isocratic chromatographic method (CO 2 :methanol 95:5) was developed on Shim-pack UC Phenyl column. The extraction method was examined with a 3-level full factorial design of experiments to optimize the extraction temperature (40 °C) and pressure (200 bar). The online SFE-SFC-MS method was compared to offline methods where the samples were extracted with liquid solvents at atmospheric pressure or high pressure then analysed with SFC-MS. In all cases, offline methods showed significant contaminants (like the oleamide lubricant) issuing from laboratory plastic materials as nitrogen drying station, syringes and filters, while the online method allowed a complete elimination of laboratory contaminations. Furthermore, the online method saved time, solvents and laboratory consumables. It will also show that transferring a compressible fluid from a loading loop is favourable to high efficiency, as the resulting chromatographic peaks are much thinner than when transferring a liquid. Compared to injecting liquid heptane, the efficiency increase was 3.4-fold, while compared to injecting liquid methanol (a common practice in SFC), the efficiency increase was 13-fold. Finally, the additive composition of different laboratory gloves was compared.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Benjamin Caux reports financial support was provided by Agence Nationale pour la Recherche et la Technologie (ANRT). Caroline West reports equipment, drugs, or supplies was provided by Shimadzu Corporation. The corresponding author is a guest editor for the virtual special issue in which this paper is submitted. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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